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. 2017 Jun;4(2):88-95.
doi: 10.1007/s40588-017-0064-8. Epub 2017 Apr 17.

Cryptococcosis today: It is not all about HIV infection

Jane A O'Halloran  1 , William G Powderly  1 , Andrej Spec  1
Affiliations

Cryptococcosis today: It is not all about HIV infection

Jane A O'Halloran et al. Curr Clin Microbiol Rep. 2017 Jun.

Abstract

Purpose of the review: Cryptococcal disease is most often thought of in the context of HIV infection. Much of our knowledge of the disease originates from its management in the HIV-positive population over the last 30 years. While the majority of cases globally continue to occur in the setting of advanced HIV, Cryptococcus species is increasingly responsible for disease in HIV-negative populations including those considered normal hosts and these HIV-negative populations will be the focus of this review.

Recent findings: Currently available data indicated that significant differences exist in epidemiology, clinical presentation, management and outcomes of cryptococcal disease in HIV-negative populations when compared to those living with HIV.

Summary: Further research is required to improve our knowledge of cryptococcal disease in particular in HIV-negative cohorts so as to optimise management of the disease in the future.

Keywords: Cryptococcosis; non-HIV; transplant.

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Conflict of interest statement

Compliance with Ethics Guidelines: Conflict of Interest: Dr. O'Halloran has nothing to disclose.

Figures

Figure 1
Figure 1
(a) Extensive localised cryptococcal skin infection at time of diagnosis (b) skin lesion following 2 weeks of treatment with liposomal amphotericin B and flucytosine.
See this image and copyright information in PMC

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