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Review
. 2017 Nov 13;18(12):100.
doi: 10.1007/s11934-017-0748-x.

Recent Developments in the Search for Urinary Biomarkers in Bladder Cancer

Aaron Leiblich  1   2
Affiliations
Review

Recent Developments in the Search for Urinary Biomarkers in Bladder Cancer

Aaron Leiblich. Curr Urol Rep. .

Abstract

Purpose of review: This review aims to evaluate research surrounding the utility of urinary biomarkers to detect bladder cancer and predict recurrence.

Recent findings: Recent research has focussed on the evaluation of genetic markers found in urine to provide diagnostic and prognostic information. Furthermore, the isolation and characterisation of extracellular vesicles (EVs) from the urine patients with bladder cancer provide an exciting new development in biomarker research that is set to expand in the coming years. Current urinary biomarker research is a broad field that encompasses the evaluation of urinary proteins, DNA, RNA and EVs to detect signatures that can be used to predict the presence of bladder cancer and provide prognostic information. EVs in particular offer an exciting and novel perspective in the search for accurate bladder cancer biomarkers.

Keywords: Bladder cancer; Exosomes; Extracellular vesicles; MicroRNA; Urinary biomarkers.

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Conflict of interest statement

Conflict of Interest

Aaron Leiblich declares no potential conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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