Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Feb;21(2-3):117-23.
doi: 10.1016/0165-5728(89)90167-7.

Peripheral nerve lesion produces increased levels of major histocompatibility complex antigens in the central nervous system

W J Streit  1 , M B Graeber, G W Kreutzberg
Affiliations

Peripheral nerve lesion produces increased levels of major histocompatibility complex antigens in the central nervous system

W J Streit et al. J Neuroimmunol. 1989 Feb.

Abstract

Proliferation of central nervous system (CNS) glia in response to peripheral nerve injury occurs without apparent participation of cells of the immune system. It is shown here that following transection of the rat facial nerve there is strongly elevated expression of class I, and to a lesser extent, class II antigens of the major histocompatibility complex (MHC) in the facial nucleus. It is demonstrated by double-immunofluorescence studies that the cells responsible for increased levels of MHC class I antigens are endogenous brain microglia. These findings emphasize the thought that microglia are immunocompetent cells, but, at the same time, raise the possibility for a non-immunological function of MHC antigens under conditions of neural regeneration.

PubMed Disclaimer

References

    1. Bignami A., Eng L.F., Uyeda C.T. Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence. Brain Res. 1972;43:429–435. - PubMed
    1. Fontana A., Fierz W., Wekerle H. Astrocytes present myelin basic protein to encephalitogenic T-cell lines. Nature. 1984;307:273–276. - PubMed
    1. Giulian D. Ameboid microglia as effectors of inflammation in the central nervous system. J. Neurosci. Res. 1987;18:155–171. - PubMed
    1. Graeber M.B., Kreutzberg G.W. Astrocytes increase in glial fibrillary acidic protein during retrograde changes of facial motor neurons. J. Neurocytol. 1986;15:363–373. - PubMed
    1. Graeber M.B., Tetzlaff W., Streit W.J., Kreutzberg G.W. Microglial cells but not astrocytes undergo mitosis following rat facial nerve axotomy. Neurosci. Lett. 1988;85:317–321. - PubMed

Substances