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Review
. 2018 Feb;51(1):e12405.
doi: 10.1111/cpr.12405. Epub 2017 Nov 12.

Emerging roles of MicroRNAs in osteonecrosis of the femoral head

Zheng Li  1 , Bo Yang  1 , Xisheng Weng  1 , Gary Tse  2 , Matthew T V Chan  3 , William Ka Kei Wu  3   4
Affiliations
Review

Emerging roles of MicroRNAs in osteonecrosis of the femoral head

Zheng Li et al. Cell Prolif. 2018 Feb.

Abstract

Osteonecrosis of the femoral head (ONFH) is one of the most common orthopaedic diseases. The exact pathogenic mechanism of ONFH is still unknown. MicroRNAs (miRNAs) are a class of non-coding RNAs that negatively modulate gene expression at post-transcriptional level. An increasing number of studies have shown that miRNAs play crucial roles in different physiological processes, including development, cell proliferation, differentiation and metabolism. Recently, multiple studies demonstrated that miRNAs are involved in the pathogenesis of ONFH. In this review, we summarize dysregulated miRNAs and their functions in ONFH. Furthermore, we discuss their potential clinical applications for diagnosis and treatment of ONFH.

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Conflict of interest statement

The authors declare no competing financial interests.

Figures

Figure 1
Figure 1
Functional role of specific miRNAs in osteonecrosis of the femoral head
See this image and copyright information in PMC

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