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. 2018 Jan;9(1):146-151.
doi: 10.1111/1759-7714.12556. Epub 2017 Nov 13.

Association between plasma fibrinogen and survival in patients with small-cell lung carcinoma

Shanshan Fan  1 , Yin Guan  1 , Guanfei Zhao  2 , Guangyu An  1
Affiliations

Association between plasma fibrinogen and survival in patients with small-cell lung carcinoma

Shanshan Fan et al. Thorac Cancer. 2018 Jan.

Abstract

Background: Elevated plasma fibrinogen (Fbg) levels contribute to tumor progression and metastasis; however, limited research on Fbg in small cell lung cancer (SCLC) has been conducted. This study evaluated the prognostic value of Fbg levels in patients with SCLC.

Methods: Data on plasma Fbg level, clinical features, and overall survival were retrospectively collected. Kaplan-Meier estimates and log-rank tests were used to analyze the relationship between Fbg level and survival. Multivariate analyses were performed to determine independent prognostic factors. Subgroup analyses were performed based on extensive/limited disease and Eastern Cooperative Oncology Group status.

Results: A total of 120 patients with SCLC were included. The one, three, and five-year survival rates for the entire cohort were 48.3%, 9.2%, and 1.7%, respectively. Univariate analyses revealed that age, alcohol use, clinical stage, pleural effusion, Eastern Cooperative Oncology Group grade, and Fbg and lactate dehydrogenase levels were associated with survival (P < 0.05). The median survival time for patients with high Fbg levels (> 400 mg/dL) was shorter than for those with low Fbg levels (8 vs. 14 months; P = 0.013). Furthermore, multivariate analysis revealed that Fbg was negatively and independently associated with SCLC prognosis (hazard ratio 1.505, 95% confidence interval 1.018-2.226; P = 0.041). Higher Fbg levels were associated with shorter survival in the extensive disease subgroup (7 vs. 12 months; P = 0.004).

Conclusions: Elevated plasma Fbg was an independent factor associated with poor outcomes in SCLC patients and could serve as a prognostic biomarker.

Keywords: Fibrinogen; prognosis; small-cell lung carcinoma; survival.

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Figures

Figure 1
Figure 1
Kaplan–Meier curves of overall survival of patients stratified by fibrinogen level (P = 0.013).
Figure 2
Figure 2
Kaplan–Meier curves of overall survival stratified by fibrinogen level. (a) Extensive disease (P = 0.004), (b) limited disease (P = 0.994), (c) Eastern Cooperative Oncology Group (ECOG) grade 3–4 (P = 0.055), and (d) ECOG grade 0–2 (P = 0.169) subgroups.
See this image and copyright information in PMC

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