Ceftriaxone-Resistant Neisseria gonorrhoeae, Canada, 2017
- PMID: 29131780
- PMCID: PMC5782888
- DOI: 10.3201/eid2402.171756
Ceftriaxone-Resistant Neisseria gonorrhoeae, Canada, 2017
Abstract
We identified a ceftriaxone-resistant Neisseria gonorrhoeae isolate in a patient in Canada. This isolate carried the penA-60 allele, which differs substantially from its closest relative, mosaic penA XXVII (80% nucleotide identity). Epidemiologic and genomic data suggest spread from Asia. Antimicrobial susceptibility surveillance helps prevent spread of highly resistant N. gonorrhoeae strains.
Keywords: Canada; Neisseria gonorrhoeae; North America; antimicrobial resistance; antimicrobial susceptibility surveillance; bacteria; ceftriaxone; ceftriaxone-resistant; gonorrhea; mosaic penA allele; penA-60; sexually transmitted infections.
Comment in
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Ceftriaxone-Resistant Neisseria gonorrhoeae, Canada, 2017.Emerg Infect Dis. 2018 Mar;24(3):608. doi: 10.3201/eid2403.171892. Epub 2018 Mar 17. Emerg Infect Dis. 2018. PMID: 29190210 Free PMC article. No abstract available.
References
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- Public Health Agency of Canada. Canadian guidelines on sexually transmitted infections ‒ management and treatment of specific infections ‒ gonococcal infections. 2013. [cited 2017 Oct 23]. http://www.phac-aspc.gc.ca/std-mts/sti-its/cgsti-ldcits/section-5-6-eng.php
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- Ohnishi M, Golparian D, Shimuta K, Saika T, Hoshina S, Iwasaku K, et al. Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxone. Antimicrob Agents Chemother. 2011;55:3538–45. 10.1128/AAC.00325-11 - DOI - PMC - PubMed
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