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Case Reports
. 2018 Feb;24(2):381-383.
doi: 10.3201/eid2402.171756. Epub 2018 Feb 17.

Ceftriaxone-Resistant Neisseria gonorrhoeae, Canada, 2017

Case Reports

Ceftriaxone-Resistant Neisseria gonorrhoeae, Canada, 2017

Brigitte Lefebvre et al. Emerg Infect Dis. 2018 Feb.

Abstract

We identified a ceftriaxone-resistant Neisseria gonorrhoeae isolate in a patient in Canada. This isolate carried the penA-60 allele, which differs substantially from its closest relative, mosaic penA XXVII (80% nucleotide identity). Epidemiologic and genomic data suggest spread from Asia. Antimicrobial susceptibility surveillance helps prevent spread of highly resistant N. gonorrhoeae strains.

Keywords: Canada; Neisseria gonorrhoeae; North America; antimicrobial resistance; antimicrobial susceptibility surveillance; bacteria; ceftriaxone; ceftriaxone-resistant; gonorrhea; mosaic penA allele; penA-60; sexually transmitted infections.

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References

    1. Public Health Agency of Canada. Canadian guidelines on sexually transmitted infections ‒ management and treatment of specific infections ‒ gonococcal infections. 2013. [cited 2017 Oct 23]. http://www.phac-aspc.gc.ca/std-mts/sti-its/cgsti-ldcits/section-5-6-eng.php
    1. Cámara J, Serra J, Ayats J, Bastida T, Carnicer-Pont D, Andreu A, et al. Molecular characterization of two high-level ceftriaxone-resistant Neisseria gonorrhoeae isolates detected in Catalonia, Spain. J Antimicrob Chemother. 2012;67:1858–60. 10.1093/jac/dks162 - DOI - PubMed
    1. Deguchi T, Yasuda M, Hatazaki K, Kameyama K, Horie K, Kato T, et al. New clinical strain of Neisseria gonorrhoeae with decreased susceptibility to ceftriaxone, Japan. Emerg Infect Dis. 2016;22:142–4. 10.3201/eid2201.150868 - DOI - PMC - PubMed
    1. Lahra MM, Ryder N, Whiley DM. A new multidrug-resistant strain of Neisseria gonorrhoeae in Australia. N Engl J Med. 2014;371:1850–1. 10.1056/NEJMc1408109 - DOI - PubMed
    1. Ohnishi M, Golparian D, Shimuta K, Saika T, Hoshina S, Iwasaku K, et al. Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxone. Antimicrob Agents Chemother. 2011;55:3538–45. 10.1128/AAC.00325-11 - DOI - PMC - PubMed

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