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. 2017 Nov 13;17(1):757.
doi: 10.1186/s12885-017-3754-y.

Diet and endometrial cancer: a focus on the role of fruit and vegetable intake, Mediterranean diet and dietary inflammatory index in the endometrial cancer risk

Fulvio Ricceri  1   2 , Maria Teresa Giraudo  3 , Francesca Fasanelli  4 , Dario Milanese  3 , Veronica Sciannameo  2 , Laura Fiorini  4 , Carlotta Sacerdote  5
Affiliations

Diet and endometrial cancer: a focus on the role of fruit and vegetable intake, Mediterranean diet and dietary inflammatory index in the endometrial cancer risk

Fulvio Ricceri et al. BMC Cancer. .

Abstract

Background: Endometrial cancer is the fourth most common cancer in European women. The major risk factors for endometrial cancer are related to the exposure of endometrium to estrogens not opposed to progestogens, that can lead to a chronic endometrial inflammation. Diet may play a role in cancer risk by modulating chronic inflammation.

Methods: In the framework of a case-control study, we recruited 297 women with newly diagnosed endometrial cancer and 307 controls from Northern Italy. Using logistic regression, we investigated the role of fruit and vegetable intake, adherence to the Mediterranean diet (MD), and the dietary inflammatory index (DII) in endometrial cancer risk.

Results: Women in the highest quintile of vegetable intake had a statistically significantly lower endometrial cancer risk (adjusted OR 5th quintile vs 1st quintile: 0.34, 95% CI 0.17-0.68). Women with high adherence to the MD had a risk of endometrial cancer that was about half that of women with low adherence to the MD (adjusted OR: 0.51, 95% CI 0.39-0.86). A protective effect was detected for all the lower quintiles of DII, with the highest protective effect seen for the lowest quintile (adjusted OR 5th quintile vs 1st quintile: 3.28, 95% CI 1.30-8.26).

Conclusions: These results suggest that high vegetable intake, adherence to the MD, and a low DII are related to a lower endometrial cancer risk, with several putative connected biological mechanisms that strengthen the biological plausibility of this association.

Keywords: Case-control study; Dietary inflammatory index; Endometrial cancer; Fruits and vegetables; Mediterranean diet.

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Conflict of interest statement

Ethics approval and consent to participate

The research have been approved by the Human Genetics Foundation (HuGeF) and University of Turin ethical committee and all subjects enrolled in the study signed an informed consent form.

Competing interests

The authors declare no potential conflicts of interest in connection with the paper.

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References

    1. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JW, Comber H, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer. 2013;49(6):1374–1403. doi: 10.1016/j.ejca.2012.12.027. - DOI - PubMed
    1. Steliarova-Foucher E, O'Callaghan M, Ferlay J, Masuyer E, Rosso S, Forman D, et al. European cancer observatory: cancer incidence, mortality, prevalence and survival in Europe. Version 1.0. Lyon: European Network of Cancer Registries, International Agency for Research on Cancer; 2015.
    1. Kaaks R, Lukanova A, Kurzer MS. Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. Cancer Epidemiol Biomark Prev. 2002;11(12):1531–1543. - PubMed
    1. Dossus L, Lukanova A, Rinaldi S, Allen N, Cust AE, Becker S, et al. Hormonal, metabolic, and inflammatory profiles and endometrial cancer risk within the EPIC cohort-a factor analysis. Am J Epidemiol. 2013;177(8):787–799. doi: 10.1093/aje/kws309. - DOI - PubMed
    1. Modugno F, Ness RB, Chen C, Weiss NS. Inflammation and endometrial cancer: a hypothesis. Cancer Epidemiol Biomark Prev. 2005;14(12):2840–2847. doi: 10.1158/1055-9965.EPI-05-0493. - DOI - PubMed