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. 2017 Nov 13;36(1):36.
doi: 10.1186/s41043-017-0114-0.

Framingham risk score for estimation of 10-years of cardiovascular diseases risk in patients with metabolic syndrome

Leila Jahangiry  1 , Mahdieh Abbasalizad Farhangi  2 , Fatemeh Rezaei  3
Affiliations

Framingham risk score for estimation of 10-years of cardiovascular diseases risk in patients with metabolic syndrome

Leila Jahangiry et al. J Health Popul Nutr. .

Abstract

Background: There are a few studies evaluating the predictive value of Framingham risk score (FRS) for cardiovascular disease (CVD) risk assessment in patients with metabolic syndrome in Iran. Because of the emerging high prevalence of CVD among Iranian population, it is important to predict its risk among populations with potential predictive tools. Therefore, the aim of the current study is to evaluate the FRS and its determinants in patients with metabolic syndrome.

Methods: In the current cross-sectional study, 160 patients with metabolic syndrome diagnosed according to the National Cholesterol Education Adult Treatment Panel (ATP) III criteria were enrolled. The FRS was calculated using a computer program by a previously suggested algorithm.

Results: Totally, 77.5, 16.3, and 6.3% of patients with metabolic syndrome were at low, intermediate, and high risk of CVD according to FRS categorization. The highest prevalence of all of metabolic syndrome components were in low CVD risk according to the FRS grouping (P < 0.05), while the lowest prevalence of these components was in high CVD risk group (P < 0.05). According to multiple logistic regression analysis, high systolic blood pressure (SBP) and fasting serum glucose (FSG) were potent determinants of intermediate and high risk CVD risk of FRS scoring compared with low risk group (P < 0.05).

Conclusion: In the current study, significant associations between components of metabolic syndrome and different FRS categorization among patients with metabolic syndrome were identified. High SBP and FSG were associated with meaningfully increased risk of CVD compared with other parameters.

Trial registrations: The study is not a trial; the registration number is not applicable.

Keywords: Cardiovascular disease; Framingham risk score; Metabolic syndrome.

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Conflict of interest statement

Competing interest

The authors declare that they have no competing interests.

Ethics approval and consent to participate

The protocol of the current study has been approved by the ethics committee of Tehran University of Medical Sciences (97/130/1736) and Ethics committee of Tabriz University of Medical Sciences (5/92/1228), and written informed consent was obtained from all of the participant’s prior participation in the study.

Consent for publication

All of the authors have read and approved the article draft and were in agreement of article submission.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Association between Framingham risk score risk categories and number of metabolic syndrome components
See this image and copyright information in PMC

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