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Editorial
. 2017 Nov 14;136(20):1936-1938.
doi: 10.1161/CIRCULATIONAHA.117.031190.

Human Endogenous Retrovirus K and Pulmonary Arterial Hypertension: A New Take on a Retro Idea

Miranda K Culley  1 , Stephen Y Chan  2   3
Affiliations
Editorial

Human Endogenous Retrovirus K and Pulmonary Arterial Hypertension: A New Take on a Retro Idea

Miranda K Culley et al. Circulation. .
No abstract available

Keywords: Editorials; endogenous retrovirus; immune activation.

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Conflict of interest statement

M.K. Culley declares no conflicts of interest.

Figures

Figure.
Figure.. HERV-K may initiate or propagate the inflammation that defines pulmonary arterial hypertension.
Saito and colleagues propose a role for HERV-K in the pathogenesis of PAH. Specifically, HERV-K components induce SAMDH1 expression, resulting in cytokine release, endothelial apoptosis, and B-cell activation. How HERV-K is activated or its diagnostic and therapeutic implications are still undefined. HERV-K indicates human endogenous retrovirus K; IL, interleukin; PAH, pulmonary arterial hypertension; and TNF, tumor necrosis factor.
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References

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