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Comment
. 2017 Dec;27(12):1403-1404.
doi: 10.1038/cr.2017.140. Epub 2017 Nov 14.

Hunting for the mutant without the MAP(K)

Leon Tejwani  1   2   3 , Janghoo Lim  1   2   3   4
Affiliations
Comment

Hunting for the mutant without the MAP(K)

Leon Tejwani et al. Cell Res. 2017 Dec.

Abstract

In a paper recently published in Cell Research, Yu et al. identify two MAPK-related kinases, MAPK11 and HIPK3, as positive regulators of levels of mutant huntingtin protein, a toxic species highly involved in Huntington's disease (HD) pathology. The identification and validation of these kinases as therapeutic targets for knockdown in multiple relevant experimental model systems reveal novel potential approaches for treatment of HD.

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