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. 2017 Nov 14;9(11):1244.
doi: 10.3390/nu9111244.

The Association between Serum 25(OH)D Status and Blood Pressure in Participants of a Community-Based Program Taking Vitamin D Supplements

Naghmeh Mirhosseini  1 , Hassanali Vatanparast  2 , Samantha M Kimball  3
Affiliations

The Association between Serum 25(OH)D Status and Blood Pressure in Participants of a Community-Based Program Taking Vitamin D Supplements

Naghmeh Mirhosseini et al. Nutrients. .

Abstract

Background: Vitamin D deficiency is a risk factor for hypertension.

Methods: We assessed 8155 participants in a community-based program to investigate the association between serum 25-hydroxyvitamin D (25(OH)D) status and blood pressure (BP) and the influence of vitamin D supplementation on hypertension. Participants were provided vitamin D supplements to reach a target serum 25(OH)D > 100 nmol/L. A nested case-control study was conducted to examine the effect of achieving physiological vitamin D status in those who were hypertensive and not taking BP-lowering medication, and hypertensive participants that initiated BP-lowering medication after program entry.

Results: At baseline, 592 participants (7.3%) were hypertensive; of those, 71% were no longer hypertensive at follow-up (12 ± 3 months later). There was a significant negative association between BP and serum 25(OH)D level (systolic BP: coefficient = -0.07, p < 0.001; diastolic BP: coefficient = -0.1, p < 0.001). Reduced mean systolic (-18 vs. -14 mmHg) and diastolic (-12 vs. -12 mmHg) BP, pulse pressure (-5 vs. -1 mmHg) and mean arterial pressure (-14 vs. -13 mmHg) were not significantly different between hypertensive participants who did and did not take BP-lowering medication.

Conclusion: Improved serum 25(OH)D concentrations in hypertensive individuals who were vitamin D insufficient were associated with improved control of systolic and diastolic BP.

Keywords: 25-hydroxyvitamin D; blood pressure; hypertension; medication; vitamin D supplement.

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Conflict of interest statement

The author’s declare no conflict of interest. Samantha Kimball and Naghmeh Mirhosseini are employed by the Pure North S’Energy Foundation. This affiliation does not alter authors’ adherence to all Nutrients policies on sharing data and materials.

Figures

Figure 1
Figure 1
Flowchart of Database Analyses Approach.
See this image and copyright information in PMC

References

    1. Mittal B.V., Singh A.K. Hypertension in the developing world: Challenges and opportunities. Am. J. Kidney Dis. 2010;55:590–598. doi: 10.1053/j.ajkd.2009.06.044. - DOI - PubMed
    1. Holick M.F. Vitamin D: Important for prevention of osteoporosis, cardiovascular heart disease, type 1 diabetes, autoimmune diseases, and some cancers. South Med. J. 2005;98:1024–1027. doi: 10.1097/01.SMJ.0000140865.32054.DB. - DOI - PubMed
    1. Colley R.C., Garriguet D., Janssen I., Craig C.L., Clarke J., Trembla M.S. Physical activity of Canadian adults: Accelerometer results from the 2007 to 2009 Canadian health measures survey. Health Rep. 2011;22:7–14. - PubMed
    1. Warburton D.E., Charlesworth S., Ivey A., Nettlefold L., Bredin S.S. A systematic review of the evidence for Canada’s physical activity guidelines for adults. Int. J. Behav. Nutr. Phys. Act. 2010;7:39. doi: 10.1186/1479-5868-7-39. - DOI - PMC - PubMed
    1. Elmer P.J., Obarzanek E., Vollmer W.M., Simons-Morton D., Stevens V.J., Young D.R., Lin P.H., Champagne C., Harsha D.W., Svetkey L.P., et al. Effects of Comprehensive Lifestyle Modification on Diet, Weight, Physical Fitness, and Blood Pressure Control: 18-Month Results of a Randomized Trial. Ann. Intern. Med. 2006;144:485–495. doi: 10.7326/0003-4819-144-7-200604040-00007. - DOI - PubMed

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