Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Nov 14;14(11):e1002436.
doi: 10.1371/journal.pmed.1002436. eCollection 2017 Nov.

Prospects for passive immunity to prevent HIV infection

Affiliations
Review

Prospects for passive immunity to prevent HIV infection

Lynn Morris et al. PLoS Med. .

Abstract

In a Perspective, Lynn Morris and Nonhlanhla Mkhize discuss the prospects for broadly neutralizing antibodies to be used in preventing HIV infection.

PubMed Disclaimer

Conflict of interest statement

I have read the journal's policy and the authors of this manuscript have the following competing interests: LM and NM are responsible for the VRC01 sensitivity testing on the AMP trial funded through the HIV Vaccines Trials Network (HVTN). LM and NM receive funding from the NIH, BMGF CAVD program, South African Medical Research Council, and CAPRISA.

Figures

Fig 1
Fig 1. Another possible weapon against HIV.
An illustration of the principles of using a monoclonal antibody as passive immunization to prevent HIV infection, as compared with the more traditional vaccine approach of active immunization. Created by Nolo Moima, Sunday Times, and Carina Kriel, NICD.

References

    1. UNAIDS. Fact sheet—Latest statistics on the status of the AIDS epidemic. [cited 22 September 2017]. http://www.unaids.org/en/resources/fact-sheet
    1. Corey L, Gray GE. Preventing acquisition of HIV is the only path to an AIDS-free generation. Proc Natl Acad Sci U S A. 2017;114(15):3798–800. doi: 10.1073/pnas.1703236114 - DOI - PMC - PubMed
    1. Graham BS, Ambrosino DM. History of passive antibody administration for prevention and treatment of infectious diseases. Curr Opin HIV AIDS. 2015;10(3):129–34. doi: 10.1097/COH.0000000000000154 - DOI - PMC - PubMed
    1. Pegu A, Hessell AJ, Mascola JR, Haigwood NL. Use of broadly neutralizing antibodies for HIV-1 prevention. Immunol Rev. 2017;275(1):296–312. doi: 10.1111/imr.12511 - DOI - PMC - PubMed
    1. Bar KJ, Sneller MC, Harrison LJ, Justement JS, Overton ET, Petrone ME, et al. Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption. N Engl J Med. 2016;375(21):2037–50. doi: 10.1056/NEJMoa1608243 - DOI - PMC - PubMed