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Comment
. 2017 Nov 13;32(5):546-547.
doi: 10.1016/j.ccell.2017.10.012.

Does CSF1R Blockade Turn into Friendly Fire?

Tim F Greten  1
Affiliations
Comment

Does CSF1R Blockade Turn into Friendly Fire?

Tim F Greten. Cancer Cell. .

Abstract

In this issue of Cancer Cell, Kumar et al. describe how CSF1R blockade induces not only an expected deprivation of tumor-associated macrophages, but also an accumulation of tumor-infiltrating polymorphonuclear mononuclear cells caused by Cxcl-1 released from cancer-associated fibroblasts.

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Figures

Figure 1.
Figure 1.. CSF1R Inhibition and Anti-Tumor Immunity
Shown is the effect of CSF-1, CSF1R, and CSF1R+ CXCR2 blockade on anti-tumor immunity. (A) Tumor-secreted CSF-1 leads to an accumulation of TAM imparing anti-tumor immunity. (B) CSF1R blockade depletes TAM but also causes an accumulation of PMN-MDSC due to Cxcl-1 secretion from CAF, which is dependent on CSF-1. This results again in an ineffective anti-tumor immunity. (C) Combined CSF1R and CXCR2 blockade reduces the number of TAMs and PMN-MDSC in the tumor microenvironment, leading to enhanced anti-tumor immunity.
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