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. 2017 Sep 20;8(48):84506-84514.
doi: 10.18632/oncotarget.21108. eCollection 2017 Oct 13.

The clinical use of the platelet to lymphocyte ratio and lymphocyte to monocyte ratio as prognostic factors in renal cell carcinoma: a systematic review and meta-analysis

Xuemin Wang  1 , Shiqiang Su  1 , Yuanshan Guo  1
Affiliations

The clinical use of the platelet to lymphocyte ratio and lymphocyte to monocyte ratio as prognostic factors in renal cell carcinoma: a systematic review and meta-analysis

Xuemin Wang et al. Oncotarget. .

Abstract

Conflicting evidence exists regarding the effect of platelet to lymphocyte ratio (PLR) and lymphocyte to monocyte ratio (LMR) on the prognosis of renal cell carcinoma (RCC) patients. Here we quantify the prognostic impact of these biomarkers and assess their consistency in RCC. Eligible studies were retrieved from the PubMed, Embase and Web of Science databases. Pooled hazard ratios (HRs), odds ratios (ORs), and 95% confidence intervals (CIs) were calculated. Sixteen studies containing 6,223 patients met criteria for inclusion. Overall, elevated PLR was associated with poorer overall survival (OS, HR 1.76, 95% CI 1.41-2.19, P < 0.001), progression-free survival (PFS, HR 2.81, 95% CI 1.40-5.63, P = 0.004) and recurrence-free survival (RFS, HR 2.64, 95% CI 1.35-5.14, P = 0.004). Conversely, high LMR was correlated with more favorable OS (HR 0.62, 95% CI 0.51-0.77, P < 0.001) and RFS (HR 0.53, 95% CI 0.42-0.67, P < 0.001). Moreover, low LMR was significantly associated with some clinicopathological characteristics that are indicative of poor prognosis and disease aggressiveness. By these results, elevated PLR was associated with poor outcomes, while high LMR correlated with more favorable survival in RCC patients. Pretreatment PLR and LMR can serve as prognostic factors in RCC patients.

Keywords: inflammation; lymphocyte to monocyte ratio; platelet to lymphocyte ratio; prognosis; renal cell carcinoma.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1. Flowchart shows the selection of literature for meta-analysis
Figure 2
Figure 2. Forest plot reflects the association between PLR and oncologic outcomes
OS = overall survival, PFS = progression-free survival, RFS = recurrence-free survival.
Figure 3
Figure 3. Forest plot reflects the association between LMR and oncologic outcomes
OS = overall survival, PFS = progression-free survival, RFS = recurrence-free survival.
Figure 4
Figure 4. Funnel plot for publication bias
(A) correlation of PLR with OS; (B) correlation of LMR with OS
See this image and copyright information in PMC

References

    1. Rini BI, Campbell SC, Escudier B. Renal cell carcinoma. Lancet. 2009;373:1119–32. https://doi.org/10.1016/s0140-6736(09)60229-4. - DOI - PubMed
    1. Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ, He J. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66:115–32. https://doi.org/10.3322/caac.21338. - DOI - PubMed
    1. Ljungberg B, Bensalah K, Canfield S, Dabestani S, Hofmann F, Hora M, Kuczyk MA, Lam T, Marconi L, Merseburger AS, Mulders P, Powles T, Staehler M, et al. Update. EAU Guidelines on Renal Cell Carcinoma. Eur Urol. 20142015 https://doi.org/10.1016/j.eururo.2015.01.005. - DOI - PubMed
    1. Moch H, Artibani W, Delahunt B, Ficarra V, Knuechel R, Montorsi F, Patard JJ, Stief CG, Sulser T, Wild PJ. Reassessing the current UICC/AJCC TNM staging for renal cell carcinoma. Eur Urol. 2009;56:636–43. https://doi.org/10.1016/j.eururo.2009.06.036. - DOI - PubMed
    1. Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454:436–44. https://doi.org/10.1038/nature07205. - DOI - PubMed

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