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Comment
. 2017 Dec 4;216(12):3891-3893.
doi: 10.1083/jcb.201710028. Epub 2017 Nov 14.

Apical polarization and lumenogenesis: The apicosome sheds new light

Alejandra I Romero-Morales  1 , Natalya A Ortolano  1 , Vivian Gama  2   3
Affiliations
Comment

Apical polarization and lumenogenesis: The apicosome sheds new light

Alejandra I Romero-Morales et al. J Cell Biol. .

Abstract

Establishment of apico-basal polarity is critical for the lumenal epiblast-like morphogenesis of human pluripotent stem cells (hPSCs). In this issue, Taniguchi et al. (2017. J Cell Biol. https://doi.org/10.1083.jcb201704085) describe a structure called the apicosome, generated in single hPSCs, that allows them to self-organize and form the lumenal epiblast-like stage.

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Figures

Figure 1.
Figure 1.
The apicosome in hPSCs initiates lumenogenesis in vitro resembling epiblast cavity formation. When plated as single cells, hPSCs self-organize and form a structure that resembles the lumenal epiblast stage. This membrane-bound structure, termed the apicosome, depends on actin assembly pathways for its formation. The inside resembles the extracellular environment. Illustration courtesy of Megan Rasmussen and Alejandra I. Romero-Morales.
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