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Review
. 2018 Mar;53(3):354-361.
doi: 10.1007/s00535-017-1407-1. Epub 2017 Nov 14.

World trends for H. pylori eradication therapy and gastric cancer prevention strategy by H. pylori test-and-treat

Hidekazu Suzuki  1 , Hideki Mori  2
Affiliations
Review

World trends for H. pylori eradication therapy and gastric cancer prevention strategy by H. pylori test-and-treat

Hidekazu Suzuki et al. J Gastroenterol. 2018 Mar.

Abstract

Helicobacter pylori-associated gastritis leads to the development of gastric cancer. Kyoto global consensus report on H. pylori gastritis recommended H. pylori eradication therapy to prevent gastric cancer. To manage H. pylori infection, it is important to choose the appropriate regimen considering regional differences in resistance to clarithromycin and metronidazole. Quinolones and rifabutin-containing regimens are useful as third- and fourth-line rescue therapies.

Keywords: Clarithromycin; Fluoroquinolone; Gastric cancer; H. pylori; Metronidazole.

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Conflict of interest statement

During the last 2 years, H.S. received scholarship funds for the research from Daiichi-Sankyo Co., Otsuka Pharmaceutical Co. Ltd., and Tsumura Co., and received service honoraria from Astellas Pharma Inc, AstraZeneca K.K., Daiichi-Sankyo Co., Otsuka Pharmaceutical Co. Ltd., Mylan EPD Co., Takeda Pharmaceutical Co., Ltd., and Zeria Pharmaceutical Co. Ltd.

Figures

Fig. 1
Fig. 1
The relationship between geographic distribution of the prevalence of H. pylori infection and the gastric cancer incidence is described. The gastric cancer incidence is generally in direct proportion to the prevalence of H. pylori infection. However, higher incidences of gastric cancer are found in East Asian countries than in the other countries
Fig. 2
Fig. 2
The geographic distribution of resistance to clarithromycin and metronidazole is described. There is only a limited relationship between geographic factor and the resistance to clarithromycin and metronidazole
Fig. 3
Fig. 3
Strategy on treatment of H. pylori infection is shown in accordance with the Maastricht V/Florence Consensus Report [40]
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