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Review
. 2018 Mar;141(3):702-710.
doi: 10.1097/PRS.0000000000004121.

State-of-the-Art Techniques in Treating Peripheral Nerve Injury

Carrie A Kubiak  1   2 , Theodore A Kung  1   2 , David L Brown  1   2 , Paul S Cederna  1   2 , Stephen W P Kemp  1   2
Affiliations
Review

State-of-the-Art Techniques in Treating Peripheral Nerve Injury

Carrie A Kubiak et al. Plast Reconstr Surg. 2018 Mar.

Abstract

Background: Peripheral nerve injuries remain a major clinical concern, as they often lead to chronic disability and significant health care expenditures. Despite advancements in microsurgical techniques to enhance nerve repair, biological approaches are needed to augment nerve regeneration and improve functional outcomes after injury.

Methods: Presented herein is a review of the current literature on state-of-the-art techniques to enhance functional recovery for patients with nerve injury. Four categories are considered: (1) electroceuticals, (2) nerve guidance conduits, (3) fat grafting, and (4) optogenetics. Significant study results are highlighted, focusing on histologic and functional outcome measures.

Results: This review documents the current state of the literature. Advancements in neuronal stimulation, tissue engineering, and cell-based therapies demonstrate promise with regard to augmenting nerve regeneration and appropriate rehabilitation.

Conclusions: The future of treating peripheral nerve injury will include multimodality use of electroconductive conduits, fat grafting, neuronal stimulation, and optogenetics. Further clinical investigation is needed to confirm the efficacy of these technologies on peripheral nerve recovery in humans, and how best to implement this treatment for a diverse population of nerve-injured patients.

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References

    1. Noble J, Munro CA, Prasad VS, Midha RAnalysis of upper and lower extremity peripheral nerve injuries in a population of patients with multiple injuries. J Trauma 1998;45:116122.
    1. National Institute of Neurological Disorders and Stroke. Peripheral neuropathy fact sheet. Available at: https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-She.... Accessed March 21, 2017.
    1. Grinsell D, Keating CPPeripheral nerve reconstruction after injury: A review of clinical and experimental therapies. Biomed Res Int. 2014;2014:698256.
    1. Wang X, Hu W, Cao Y, Yao J, Wu J, Gu XDog sciatic nerve regeneration across a 30-mm defect bridged by a chitosan/PGA artificial nerve graft. Brain 2005;128:18971910.
    1. Dellon AL, Mackinnon SEBasic scientific and clinical applications of peripheral nerve regeneration. Surg Annu. 1988;20:59100.

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