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Review
. 2017 Nov 15;31(1):e00024-17.
doi: 10.1128/CMR.00024-17. Print 2018 Jan.

Syndromic Panel-Based Testing in Clinical Microbiology

Poornima Ramanan  1 , Alexandra L Bryson  1 , Matthew J Binnicker  1 , Bobbi S Pritt  1   2 , Robin Patel  3   2
Affiliations
Review

Syndromic Panel-Based Testing in Clinical Microbiology

Poornima Ramanan et al. Clin Microbiol Rev. .

Abstract

The recent development of commercial panel-based molecular diagnostics for the rapid detection of pathogens in positive blood culture bottles, respiratory specimens, stool, and cerebrospinal fluid has resulted in a paradigm shift in clinical microbiology and clinical practice. This review focuses on U.S. Food and Drug Administration (FDA)-approved/cleared multiplex molecular panels with more than five targets designed to assist in the diagnosis of bloodstream, respiratory tract, gastrointestinal, or central nervous system infections. While these panel-based assays have the clear advantages of a rapid turnaround time and the detection of a large number of microorganisms and promise to improve health care, they present certain challenges, including cost and the definition of ideal test utilization strategies (i.e., optimal ordering) and test interpretation.

Keywords: molecular methods; multiplex PCR; syndromic testing.

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Figures

FIG 1
FIG 1
Potential testing algorithm for evaluating patients with acute gastroenteritis. (Modified and used with permission of Mayo Foundation for Medical Education and Research. All rights reserved.)
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