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. 2017 Nov 15;7(1):15667.
doi: 10.1038/s41598-017-15722-w.

Sex-specific association between asthma and hypertension in nationally representative young Korean adults

Hong Seok Lee  1   2 , Yong-Moon Park  3 , Kyungdo Han  4 , Gerald Pekler  1   5 , Seong-Su Lee  6 , Soonjib Yoo  6 , Sung Rae Kim  7
Affiliations

Sex-specific association between asthma and hypertension in nationally representative young Korean adults

Hong Seok Lee et al. Sci Rep. .

Abstract

It has been reported that people with asthma have an increased risk of hypertension. However, little is known about the specific relationship between asthma and hypertension in young adults. Among subjects who participated in the Korea National Health and Nutrition Examination Survey conducted in 2008-2013, a total of 10,138 young adults (4,226 men and 5,912 women) aged 19-39 years were analyzed. Multiple logistic regression analysis was used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs). The prevalence of ever asthma was 11.1% in men and 8.4% in women. The mean diastolic blood pressure (DBP) was lower in men with asthma than in men without asthma (p = 0.03), whereas the mean DBP was higher in women with asthma than in women without asthma (p = 0.04). Having asthma was inversely associated with hypertension in men (OR: 0.62, 95% CI: 0.41-0.91). In contrast, having asthma was positively associated with hypertension in women (OR: 2.19, 95% CI: 1.19-4.02). Our results suggest that asthma pathophysiology might be differentially associated with hypertension in young adults depending on sex.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Prevalence of asthma according to normotension, prehypertension, hypertension by sex. Hypertensive men had low prevalence of ‘ever’ asthma (p = 0.03) and hypertensive women had high prevalence of ‘ever’ asthma (p = 0.02).
Figure 2
Figure 2
(A,B) Distribution of asthma with increasing systolic and diastolic blood pressure by sex. With increasing systolic blood pressure, prevalence of ‘ever’asthma tended to decrease in men (p for trend = 0.04) and increase in women (p for trend < 0.01). Similarly, with increasing diastolic blood pressure, prevalence of ‘ever’asthma tended to decrease in men (p for trend < 0.01) and increase in women (p for trend < 0.01).
See this image and copyright information in PMC

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