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. 2017 Oct-Dec;27(4):132-140.
doi: 10.4103/jcecho.jcecho_43_17.

Carotid Artery Stiffness and Development of Hypertension in People with Paraplegia and No Overt Cardiovascular Disease: A 7-year Follow-up Study

Olga Vriz  1 , Nicole Bertin  1 , Arianna Ius  1 , Emiliana Bizzarini  2 , Eduardo Bossone  3 , Francesco Antonini-Canterin  4
Affiliations

Carotid Artery Stiffness and Development of Hypertension in People with Paraplegia and No Overt Cardiovascular Disease: A 7-year Follow-up Study

Olga Vriz et al. J Cardiovasc Echogr. 2017 Oct-Dec.

Abstract

Objectives: The aim of this study was to compare arterial stiffness between people with paraplegia and able-bodied persons (ABPs) and to assess cardiovascular markers that may be predictive of the development of arterial hypertension in people with spinal cord injury (SCI).

Setting: This study was conducted at rehabilitation Hospital, Udine (Italy).

Methods: Fifty-seven patients with SCI were prospectively enrolled and compared with 88 healthy ABPs. All patients underwent comprehensive transthoracic echocardiography, and one-point left common carotid artery (CCA) color-Doppler study for arterial stiffness.

Results: Patients with SCI had significantly lower body mass index (BMI) and diastolic blood pressure (BP) compared with ABPs, and significantly higher carotid stiffness values (and lower arterial compliance) (P < 0.05) after adjustment for age, sex, BMI, physical activity, and heart rate. The SCI patients had lower values of the right ventricular function parameters (tricuspid annular plane systolic excursion and right Sm; P < 0.0001), increased wall thickness, and impaired diastolic function. At 7-year follow-up, 10.5% of SCI patients showed high BP; they were significantly heavier with a tendency toward increased abdominal obesity after adjustment for age and systolic BP. BMI was found to be an independent predictor of the development of hypertension.

Conclusions: Patients with posttraumatic chronic SCI and no overt cardiovascular disease exhibit higher CCA stiffness along with the left and right ventricular involvement, compared with ABPs. People with paraplegia who develop arterial hypertension show increased CCA stiffness mediated by obesity. Lifestyle modifications and weight control should be promoted in all patients with SCI, even at a very early stage.

Keywords: Cardiac function; carotid artery stiffness; spinal cord injury.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Top left panel: long-axis view of the common carotid artery and ultrasound beam configuration with independent beam steering function. The solid line shows the ultrasound beam direction for velocity measurements whereas the dotted line shows the ultrasound beam direction for measurements of diameter change. Top right panel: Pink P = Pressure wave; light blue U = Velocity; Green ECG. Bottom: Arterial stiffness parameters; Diameter: Diameter of the common carotid artery; Pressure: Brachial arterial pressure and heart rate
Figure 2
Figure 2
Parameters of carotid stiffness (β-index, elastic modulus, one-point pulse wave velocity) and arterial compliance in people with paraplegia versus able-bodied persons after adjustment for age, sex, body mass index, physical activity, and heart rate
See this image and copyright information in PMC

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