Induction and Maintenance of Amenorrhea in Transmasculine and Nonbinary Adolescents
- PMID: 29142910
- PMCID: PMC5684657
- DOI: 10.1089/trgh.2017.0021
Induction and Maintenance of Amenorrhea in Transmasculine and Nonbinary Adolescents
Abstract
The treatment of persistent uterine bleeding in those patients who identify as transmasculine or nonbinary is often straightforward, but can be difficult in a subset of patients. This article reviews the physiology of the normal menstrual cycle and the hormonal influences on the endometrium, and then explores options for the treatment of persistent bleeding for people both already on testosterone and for those who are either not ready for or who do not desire testosterone.
Keywords: endometrium; gonadotropin releasing hormone analogs; progestins; secondary amenorrhea; testosterone; uterine bleeding.
Conflict of interest statement
No competing financial interests exist.
Figures
Similar articles
-
Uterine pathology in transmasculine persons on testosterone: a retrospective multicenter case series.Am J Obstet Gynecol. 2019 Mar;220(3):257.e1-257.e7. doi: 10.1016/j.ajog.2018.12.021. Epub 2018 Dec 21. Am J Obstet Gynecol. 2019. PMID: 30579875
-
The effect of testosterone on ovulatory function in transmasculine individuals.Am J Obstet Gynecol. 2020 Aug;223(2):229.e1-229.e8. doi: 10.1016/j.ajog.2020.01.059. Epub 2020 Feb 8. Am J Obstet Gynecol. 2020. PMID: 32044312 Free PMC article.
-
Hormonal Contraceptives, Intrauterine Devices, Gonadotropin-releasing Hormone Analogues and Testosterone: Menstrual Suppression in Special Adolescent Populations.J Pediatr Adolesc Gynecol. 2019 Sep;32(5S):S23-S29. doi: 10.1016/j.jpag.2019.04.007. Epub 2019 Apr 11. J Pediatr Adolesc Gynecol. 2019. PMID: 30980941 Review.
-
A Comparison of Gender-Affirming Chest Surgery in Nonbinary Versus Transmasculine Patients.Ann Plast Surg. 2020 May;84(5S Suppl 4):S323-S328. doi: 10.1097/SAP.0000000000002254. Ann Plast Surg. 2020. PMID: 32032108 Review.
-
Endometrial patterns in women on chronic luteinizing hormone-releasing hormone agonist treatment for contraception.Fertil Steril. 1981 Sep;36(3):339-42. doi: 10.1016/s0015-0282(16)45735-3. Fertil Steril. 1981. PMID: 6793403
Cited by
-
Persistent vaginal bleeding during gender-affirming hormone therapy in transgender men.J Endocrinol Invest. 2024 Aug;47(8):2053-2060. doi: 10.1007/s40618-023-02296-w. Epub 2024 Feb 1. J Endocrinol Invest. 2024. PMID: 38300501
-
Increased Surveillance or Increased Scrutiny: Curbing Inappropriate Screening of Endometrial Cancer in Transgender Men.J Family Reprod Health. 2022 Sep;16(3):170-176. J Family Reprod Health. 2022. PMID: 36569259 Free PMC article. Review.
-
CE: An Evidence-Based Update on Contraception.Am J Nurs. 2020 Feb;120(2):22-33. doi: 10.1097/01.NAJ.0000654304.29632.a7. Am J Nurs. 2020. PMID: 31977414 Free PMC article. Review.
-
Menstrual management in transgender and gender diverse individuals: psychiatric and psychosocial considerations.Front Psychiatry. 2024 Oct 29;15:1422333. doi: 10.3389/fpsyt.2024.1422333. eCollection 2024. Front Psychiatry. 2024. PMID: 39534608 Free PMC article. Review.
-
Gender-Affirming Care of Transgender and Gender-Diverse Youth: Current Concepts.Annu Rev Med. 2023 Jan 27;74:107-116. doi: 10.1146/annurev-med-043021-032007. Epub 2022 Oct 19. Annu Rev Med. 2023. PMID: 36260812 Free PMC article. Review.
References
-
- Illingworth P. Amenorrhea, anovulation, and dysfunctional uterine bleeding. In: Endocrinology: Adult and Pediatric, 6th ed. (Jameson IL, De Groot LJ; eds). Philadelphia: Saunders Elsevier, 2010, pp. 2341–2355
-
- Fraser I. Regulating menstrual bleeding. J Reprod Med. 1999;44:158–164 - PubMed
-
- Campbell S, Cameron IT. The origins and physiology of menstruation. In: Clinical Disorders of the Endometrium and Menstrual Cycle. (Cameron IT, Fraser IS, Smith SK; eds). Oxford: Oxford University Press, 1998, pp. 13–30
-
- Marshall JC, Rame NK. Hormonal regulation of the menstrual cycle, mechanisms of ovulation, premenstrual syndromes. In: Endocrinology: Adult and Pediatric, 6th ed. (Jameson IL, De Groot LJ; eds). Philadelphia: Saunders Elsevier, 2010, pp. 2327–2340
-
- The American College of Obstetricians and Gynecologists: diagnosis of abnormal uterine bleeding in reproductive aged women. Practice Bulletin No. 128. American College of Obstetricians and Gynecologists. Obstet Gynecol. 2012;120:197–206 - PubMed
Publication types
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources