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. 2017 Dec 1;19(23):6432-6435.
doi: 10.1021/acs.orglett.7b03337. Epub 2017 Nov 16.

From Ketones, Amines, and Carbon Monoxide to 4-Quinolones: Palladium-Catalyzed Oxidative Carbonylation

Jiwei Wu  1 , Yuchen Zhou  1 , Ting Wu  1 , Yi Zhou  1 , Chien-Wei Chiang  1 , Aiwen Lei  1   2
Affiliations

From Ketones, Amines, and Carbon Monoxide to 4-Quinolones: Palladium-Catalyzed Oxidative Carbonylation

Jiwei Wu et al. Org Lett. .

Abstract

A novel method of palladium-catalyzed oxidative carbonylation of ketones, amines, and carbon monoxide for the synthesis of 4-quinolones has been developed. This protocol provides a straightforward route to construct useful 4-quinolone derivatives from inexpensive chemicals.

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