Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Feb 23;399(3):203-217.
doi: 10.1515/hsz-2017-0236.

Host target-based approaches against arboviral diseases

Rebeca Froes Rocha  1   2 , Juliana Lemos Del Sarto  1   2 , Rafael Elias Marques  3 , Vivian Vasconcelos Costa  2   4 , Mauro Martins Teixeira  1   2
Affiliations
Review

Host target-based approaches against arboviral diseases

Rebeca Froes Rocha et al. Biol Chem. .

Abstract

In the 20th century, socioeconomic and environmental changes facilitated the reintroduction of mosquitoes in developing cities, resulting in the reinsertion of mosquito-borne viral diseases and the dispersal of their causative agents on a worldwide scale. Recurrent outbreaks of arboviral diseases are being reported, even in regions without a previous history of arboviral disease transmission. Of note, arboviral infections represented approximately 30% of all emerging vector-borne diseases in the last decade. Therapeutic strategies against infectious viral diseases include the use of different classes of molecules that act directly on the pathogen and/or act by optimizing the host immune response. Drugs targeting the virus usually provide amelioration of symptoms by suppressing and controlling the infection. However, it is limited by the short-window of effectiveness, ineffectiveness against latent viruses, development of drug-resistant mutants and toxic side effects. Disease may also be a consequence of an excessive, uncontrolled or misplaced inflammatory response, treatments that interfere in host immune response are interesting options and can be used isolated or in combination with virus-targeted therapies. The use of host-targeted therapies requires specific knowledge regarding host immune patterns that may trigger dengue virus (DENV), chikungunya virus (CHIKV) or Zika virus (ZIKV) disease.

Keywords: Zika virus; arboviruses; chikungunya virus; dengue virus; host target; immune response.

PubMed Disclaimer

References

    1. Aagaard, K.M., Lahon, A., Suter, M.A., Arya, R.P., Seferovic, M.D., Vogt, M.B., Hu, M., Stossi, F., Mancini, M.A., Harris, R.A., et al. (2017). Primary human placental trophoblasts are permissive for Zika virus (ZIKV) replication. Sci. Rep. 7, 41389.
    1. Aliota, M.T., Caine, E.A., Walker, E.C., Larkin, K.E., Camacho, E., and Osorio, J.E. (2016). Characterization of lethal Zika virus infection in AG129 mice. PLoS Negl. Trop. Dis. 10, e0004682.
    1. Anaya, J.-M., Rodríguez, Y., Monsalve, D.M., Vega, D., Ojeda, E., González-Bravo, D., Rodríguez-Jiménez, M., Pinto-Díaz, C.A., Chaparro, P., Gunturiz, M.L., et al. (2017). A comprehensive analysis and immunobiology of autoimmune neurological syndromes during the Zika virus outbreak in Cúcuta, Colombia. J. Autoimmun. 77, 123–138.
    1. Andrade, D.V. and Harris, E. (2017). Recent advances in understanding the adaptative immune response to Zika virus and the effect of previous flavivirus exposure. Virus Res. pii: S0168-1702(17)30462-8.
    1. Arend, W.P. (2002). The balance between IL-1 and IL-1Ra in disease. Cytokine Growth Factor Rev. 13, 323–340.

Substances

LinkOut - more resources