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Review
. 2017 Nov;96(46):e8552.
doi: 10.1097/MD.0000000000008552.

Phyllodes tumors of the breast in 2 sisters: Case report and review of literature

Yichao Wang  1 , Jingqiang Zhu, Junhe Gou, JunJie Xiong, Xiaoqin Yang
Affiliations
Review

Phyllodes tumors of the breast in 2 sisters: Case report and review of literature

Yichao Wang et al. Medicine (Baltimore). 2017 Nov.

Abstract

Rationale: Phyllodes tumors (PT) of the breast are rare neoplasm originating from fibroepithelial component. To our knowledge, our report is the first reported case of PT in 2 sisters.

Patient concerns: We presented 2 cases of PT of the breast involving in 2 sisters. On physical examination of the younger sister, a firm mass measuring approximately 3 cm in diameter was identified in upper inner quadrant of the right breast. Physical examination of the elder sister revealed a 3 cm lump in upper outer quadrant of the left breast.

Diagnoses: Histopathology of the younger sister revealed a malignant PT. The elder sister was diagnosed with borderline PT.

Interventions: The younger sister with malignant PT underwent right mastectomy. The elder sister with borderline PT was scheduled for wide resection of the mass in the left breast.

Outcomes: After a follow-up of 23 months, no local or distant recurrence was observed.

Lessons: Our cases indicate that genetic factor may contribute to the risk of PT of the breast. Markers such as p53 and Ki-67 may have some correlation with PT malignancy.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Ultrasound of younger sister's right breast showing a hypoechogenic mass with heterogeneous echotexture (A), and elder sister's left breast showing a hypoechogenic mass with internal anechoic area (B).
Figure 2
Figure 2
Hematoxylin and eosin (HE) staining of younger sister's malignant phyllodes tumors of the breast with liposarcoma component which showed large lipoblasts with vacuolated cytoplasm and eccentric marginal, hyperchromatic nuclei (A, 100 × magnification), and elder sister's borderline phyllodes tumors of the breast (B, 100 × magnification).
Figure 3
Figure 3
P53 was positively expressed in the stroma of malignant phyllodes tumors of younger sister (A, 200 × magnification) and negative for borderline phyllodes tumors of elder sister (B, 200 × magnification).
See this image and copyright information in PMC

References

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