Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2017 Nov 16;12(11):e0188171.
doi: 10.1371/journal.pone.0188171. eCollection 2017.

The effects of non-surgical periodontal treatment on glycemic control, oxidative stress balance and quality of life in patients with type 2 diabetes: A randomized clinical trial

Hirofumi Mizuno  1 , Daisuke Ekuni  1   2 , Takayuki Maruyama  3 , Kota Kataoka  1 , Toshiki Yoneda  1 , Daiki Fukuhara  1 , Yoshio Sugiura  1 , Takaaki Tomofuji  4 , Jun Wada  5 , Manabu Morita  1
Affiliations
Randomized Controlled Trial

The effects of non-surgical periodontal treatment on glycemic control, oxidative stress balance and quality of life in patients with type 2 diabetes: A randomized clinical trial

Hirofumi Mizuno et al. PLoS One. .

Abstract

Aim: The purpose of this study was to investigate the effects of non-surgical periodontal treatment on hemoglobinA1c (HbA1c) levels, oxidative stress balance and quality of life (QOL) in patients with type 2 diabetes mellitus (T2DM) compared to no periodontal treatment (simple oral hygiene instructions only).

Methods: The design was a 6-month, single-masked, single center, randomized clinical trial. Patients had both T2DM and chronic periodontitis. Forty participants were enrolled between April 2014 and March 2016 at the Nephrology, Diabetology and Endocrinology Department of Okayama University Hospital. The periodontal treatment group (n = 20) received non-surgical periodontal therapy, including scaling and root planing plus oral hygiene instructions, and consecutive supportive periodontal therapy at 3 and 6 months. The control group (n = 17) received only oral hygiene instructions without treatment during the experimental period. The primary study outcome was the change in HbA1c levels from baseline to 3 months. Secondary outcomes included changes in oxidative stress balance (Oxidative-INDEX), the Diabetes Therapy-Related QOL and clinical periodontal parameters from baseline to 3 months and baseline to 6 months.

Results: Changes in HbA1c in the periodontal treatment group were not significantly different with those in the control group at 3 and 6 months. Systemic oxidative stress balance and QOL significantly improved in the periodontal treatment group compared to the control group at 3 months. In the subgroup analysis (moderately poor control of diabetes), the decrease in HbA1c levels in the periodontal treatment group was greater than that in the control group at 3 months but not significant.

Conclusions: In T2DM patients, non-surgical periodontal treatment improved systemic oxidative stress balance and QOL, but did not decrease HbA1c levels at 3 months follow-up.

Trial registration: Current Controlled Trials UMIN-ICDR UMIN 000013278 (Registered April 1, 2014).

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flowchart of the study design.
See this image and copyright information in PMC

References

    1. Guideline Committee of the Japan Diabetes Society. Japan Diabetes Society evidence-based practice guidelines for the treatment of diabetes in Japan. 2016. http://www.fa.kyorin.co.jp/jds/uploads/GL2016-02.pdf. Cited 12 February 2017.
    1. American Diabetes Association. 3. Foundations of Care and Comprehensive Medical Evaluation. Diabetes Care. 2016; 39: S23–S35. doi: 10.2337/dc16-S006 - DOI - PubMed
    1. Löe H. Periodontal disease. The sixth complication of diabetes mellitus. Diabetes Care. 1993; 16: 329–334. - PubMed
    1. Hirschfeld L, Wasserman B. Along-termsurvey of tooth loss in 600 treated periodontal patients. J Periodontol. 1978; 49: 225–237. doi: 10.1902/jop.1978.49.5.225 - DOI - PubMed
    1. Lalla E, Papapanou PN. Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nat Rev Endocrinol. 2011; 7: 738–748. doi: 10.1038/nrendo.2011.106 - DOI - PubMed

Publication types