Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Nov 16;12(11):e0188306.
doi: 10.1371/journal.pone.0188306. eCollection 2017.

Incidence and relative risk of stroke in the diabetic and the non-diabetic population between 1998 and 2014: A community-based stroke register

Andrea Icks  1   2   3 , Heiner Claessen  2   3 , Tatjana Kvitkina  2   3 , Maria Narres  1   2   3 , Michael Weingärtner  4   5 , Stefan Schwab  6 , Peter L Kolominsky-Rabas  4   5
Affiliations

Incidence and relative risk of stroke in the diabetic and the non-diabetic population between 1998 and 2014: A community-based stroke register

Andrea Icks et al. PLoS One. .

Abstract

One major objective of the St. Vincent Declaration was to reduce excess risk of stroke in people with diabetes mellitus. The aim of this study is to estimate the trend of incidence and relative risk of stroke in the diabetic and the non-diabetic populations in Germany over a 17-year period. We estimated age-sex standardised incidence rates of all stroke and ischaemic stroke in people with and without diabetes based on an ongoing prospective community-based stroke register covering 105,000 inhabitants. Time trends were analysed using Poisson regression. In total, 3,111 individuals (diabetes: 28.4%, men 46.9%, mean age 73.1 years (SD 13.2)) had a first stroke, 84.9% of which were ischaemic stroke. Among people with diabetes we observed a significant reduction in all stroke incidence by 1.5% per year (relative risk: 0.985; 95% confidence interval 0.972-0.9995) Likewise, this incidence tended to decrease for ischaemic stroke by 1% per year (0.993; 0.979-1.008). In contrast, the incidence rate for all stroke remained nearly stable among people without diabetes (1.003; 0.993-1.013) and for ischaemic stroke (1.002; 0.991-1.013). The relative risk comparing diabetic and non-diabetic population decreased for all stroke (two percent annual reduction) but not for ischaemic stroke. Time trends were similar for both sexes regarding all and ischaemic strokes. We found a reduction in risk of stroke in the diabetic population while this rate did not materially change in the non-diabetic population.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Age–sex standardised incidence rate of stroke with and without diabetes in the total population.
Continuous lines = persons with diabetes; dotted lines = persons without diabetes; x-axis: calendar year; y-axis: incidence rate per 100,000 person years.
Fig 2
Fig 2. Age–sex standardised incidence rate of stroke with and without diabetes in the male population.
Continuous lines = persons with diabetes; dotted lines = persons without diabetes; x-axis: calendar year; y-axis: incidence rate per 100,000 person years.
Fig 3
Fig 3. Age–sex standardised incidence rate of stroke with and without diabetes in the female population.
Continuous lines = persons with diabetes; dotted lines = persons without diabetes; x-axis: calendar year; y-axis: incidence rate per 100,000 person years.
Fig 4
Fig 4. Age–sex standardised incidence rate of ischaemic stroke with and without diabetes in the total population.
Continuous lines = persons with diabetes; dotted lines = persons without diabetes; x-axis: calendar year; y-axis: incidence rate per 100,000 person years.
Fig 5
Fig 5. Age–sex standardised incidence rate of ischaemic stroke with and without diabetes in the male population.
Continuous lines = persons with diabetes; dotted lines = persons without diabetes; x-axis: calendar year; y-axis: incidence rate per 100,000 person years.
Fig 6
Fig 6. Age–sex standardised incidence rate of ischaemic stroke with and without diabetes in the female population.
Continuous lines = persons with diabetes; dotted lines = persons without diabetes; x-axis: calendar year; y-axis: incidence rate per 100,000 person years.
See this image and copyright information in PMC

References

    1. The Saint Vincent declaration. Diabetes care and research in Europe: the Saint Vincent declaration. Diabetic medicine: a journal of the British Diabetic Association. 1990;7(4):360. - PubMed
    1. Diabetes care and research in Europe: the Saint Vincent declaration. Diabetic medicine: a journal of the British Diabetic Association. 1990;7(4):360. - PubMed
    1. Almdal T, Scharling H, Jensen JS, Vestergaard H. The independent effect of type 2 diabetes mellitus on ischaemic heart disease, stroke, and death: a population-based study of 13,000 men and women with 20 years of follow-up. Archives of internal medicine. 2004;164(13):1422–1426. doi: 10.1001/archinte.164.13.1422 - DOI - PubMed
    1. Goldstein LB, Bushnell CD, Adams RJ, Appel LJ, Braun LT, Chaturvedi S, et al. Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke; a journal of cerebral circulation. 2011;42(2):517–584. - PubMed
    1. Mulnier HE, Seaman HE, Raleigh VS, Soedamah-Muthu SS, Colhoun HM, Lawrenson RA, et al. Risk of stroke in people with type 2 diabetes in the UK: a study using the General Practice Research Database. Diabetologia. 2006;49(12):2859–2865. doi: 10.1007/s00125-006-0493-z - DOI - PubMed

Publication types