Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Feb;180(2):460-6.
doi: 10.1016/0014-4827(89)90072-4.

The protein composition of the nuclear matrix of murine P19 embryonal carcinoma cells is differentiation-stage dependent

N Stuurman  1 , R Van Driel, L De Jong, A M Meijne, J Van Renswoude
Affiliations

The protein composition of the nuclear matrix of murine P19 embryonal carcinoma cells is differentiation-stage dependent

N Stuurman et al. Exp Cell Res. 1989 Feb.

Abstract

The protein composition of the nuclear matrix of murine P19 embryonal carcinoma (EC) cells was compared with that of clonal derivatives of P19 EC differentiated in vitro, and with that of P19 EC cells induced to differentiate with retinoic acid (RA). Several major differences in nuclear matrix protein composition were found between the cell lines tested. Some polypeptides were found to occur only in EC cells, whereas others proved to be restricted to one or more of the differentiated derivatives. During RA treatment of EC cells a transient expression of some matrix proteins was observed. Several new proteins appeared, and others disappeared. Our data indicate that the protein composition of the nuclear matrix is a sensitive gauge for the differentiation state of cells.

PubMed Disclaimer