Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Nov 16;15(1):221.
doi: 10.1186/s12955-017-0772-z.

Quality of life in children with infantile hemangioma: a case control study

Chuan Wang  1 , Yanan Li  1 , Bo Xiang  1 , Fei Xiong  2 , Kai Li  3 , Kaiying Yang  1 , Siyuan Chen  4 , Yi Ji  5
Affiliations

Quality of life in children with infantile hemangioma: a case control study

Chuan Wang et al. Health Qual Life Outcomes. .

Abstract

Background: Infantile hemangioma (IH) is the most common vascular tumor in children. It is controversial whether IHs has effects on the quality of life (QOL) in patients of whom IH poses no threat or potential for complication. Thus, we conducted this study to evaluate the q QOL in patients with IH and find the predictors of poor QOL.

Methods: The PedsQL 4.0 Genetic Core Scales and the PedsQL family information form were administered to parents of children with IH and healthy children both younger than 2-year-old. The quality-of-life instrument for IH (IH-QOL) and the PedsQL 4.0 family impact module were administered to parents of children with IH. We compared the PedsQL 4.0 Genetic Core Scales (GCIS) scores of the two groups. Multiple step-wise regression analysis was used to determine factors that influenced QOL in children with IH and their parents.

Results: Except for physical symptom, we found no significant difference in GCIS between patient group and healthy group (P = 0.409). The internal reliability of IH-QOL was excellent with the Cronbach's alpha coefficient for summary scores being 0.76. Multiple step-wise regression analysis showed that the predictors of poor IH-QOL total scores were hemangioma size, location, and mother's education level. The predictors of poor FIM total scores were hemangioma location and father's education level. The predictors of poor GCIS total scores were children's age, hemangioma location and father's education level.

Conclusion: The findings support the feasibility and reliability of the Chinese version of IH-QOL to evaluate the QOL in children with IH and their parents. Hemangioma size, location and education level of mother are important impact factors for QOL in children with IH and their parents.

Keywords: Hemangioma location; Infantile hemangioma; Pediatric quality of life inventory; QOL instrument for IH; Quality of life.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

This study was approved by the Ethics Committee of the West China Hospital of Sichuan University and West China Second University Hospital of Sichuan University. All procedures followed the research protocols approved by West China Hospital of Sichuan University and West China Second University Hospital of Sichuan University and conducted according to the Declaration of Helsinki. Written informed consents were obtained from all children’s parents.

Consent for publication

All children’s parents had provided their consent regarding the publication of this manuscript.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

References

    1. Munden A, Butschek R, Tom WL, Marshall JS, Poeltler DM, Krohne SE, et al. Prospective study of infantile haemangiomas: incidence, clinical characteristics and association with placental anomalies. Br J Dermatol. 2014;170:907–913. doi: 10.1111/bjd.12804. - DOI - PMC - PubMed
    1. Darrow DH, Greene AK, Mancini AJ, Nopper AJ. Diagnosis and management of infantile hemangioma. Pediatrics. 2015;136:e1060–e1104. doi: 10.1542/peds.2015-2485. - DOI - PubMed
    1. Drolet BA, Esterly NB, Frieden IJ. Hemangiomas in children. N Engl J Med. 1999;341:173–181. doi: 10.1056/NEJM199907153410307. - DOI - PubMed
    1. Ji Y, Chen S, Xiang B, Xu Z, Jiang X, Liu X, et al. Clinical features and management of multifocal hepatic hemangiomas in children: a retrospective study. Sci Rep. 2016;6:31744. doi: 10.1038/srep31744. - DOI - PMC - PubMed
    1. Zweegers J, van der Vleuten CJ. The psychosocial impact of an infantile haemangioma on children and their parents. Arch Dis Child. 2012;97:922–926. doi: 10.1136/archdischild-2012-302470. - DOI - PubMed

Publication types