Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Nov 14;70(20):2600-2602.
doi: 10.1016/j.jacc.2017.09.033.

Myofilament Calcium-Buffering Dependent Action Potential Triangulation in Human-Induced Pluripotent Stem Cell Model of Hypertrophic Cardiomyopathy

Myofilament Calcium-Buffering Dependent Action Potential Triangulation in Human-Induced Pluripotent Stem Cell Model of Hypertrophic Cardiomyopathy

Lili Wang et al. J Am Coll Cardiol. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

There are no relationships with industry. The authors declare no financial conflict of interest

Figures

Figure 1
Figure 1
(A) Representative cytosolic Ca buffering curves (inset) and average Kd data. (B) Representative APs (inset) and average APD50 change in response to genetic or pharmacological interventions. Values are mean ± SEM. N=12-17 CM per group, P<0.05 versus isogenic (*,#) or population (Δ) control.

References

    1. Varnava AM, et al. Hypertrophic cardiomyopathy: histopathological features of sudden death in cardiac troponin T disease. Circulation. 2001;104:1380–4. - PubMed
    1. Schober T, et al. Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis, and causes pause-dependent Ca-triggered arrhythmia. Circulation research. 2012;111:170–9. - PMC - PubMed
    1. Feaster TK, et al. Matrigel Mattress: A Method for the Generation of Single Contracting Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circulation research. 2015;117:995–1000. - PMC - PubMed
    1. Hwang HS, et al. Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories. Journal of molecular and cellular cardiology. 2015;85:79–88. - PMC - PubMed
    1. Hondeghem LM, Carlsson L, Duker G. Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic. Circulation. 2001;103:2004–13. - PubMed

Publication types

MeSH terms

LinkOut - more resources