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. 2017 Nov 16;7(1):15698.
doi: 10.1038/s41598-017-15922-4.

Incidence and mortality of kidney cancer: temporal patterns and global trends in 39 countries

Martin C S Wong  1   2 , William B Goggins  3 , Benjamin H K Yip  3 , Franklin D H Fung  3 , Colette Leung  3 , Yuan Fang  3 , Samuel Y S Wong  3   4 , C F Ng  5
Affiliations

Incidence and mortality of kidney cancer: temporal patterns and global trends in 39 countries

Martin C S Wong et al. Sci Rep. .

Abstract

We tested the hypotheses that kidney cancer incidence was increasing globally whilst its mortality was reducing; and its incidence was positively correlated with country-specific socioeconomic development. The incidence and mortality figures of each country were projected to 2030. Data on age-standardized incidence/mortality rates were retrieved from the GLOBOCAN in 2012. Temporal patterns were examined for 39 countries from the Cancer Incidence in Five Continents volumes I-X and other national registries. We evaluated the correlation between the incidence/mortality rates and Human Development Index (HDI)/Gross Domestic Product (GDP]). The average annual percent change of its incidence and mortality in the most recent 10 years was obtained from joinpoint regression. The highest incidence rates were observed in Eastern Europe and North America, while its mortality rates were the highest in European countries. Incidence was positively correlated with HDI and GDP per capita. Many countries experienced incidence rise over the most recent 10 years, and a substantial reduction in mortality rates was observed for a significant number of countries, yet increases in mortality rates were observed in Eastern Europe. By 2030, Brazil and Ecuador may have the greatest rise in incidence both in men and women, which requires urgent need for planning healthcare resources.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
The age-incidence incidence (left) and mortality (right) rates of kidney cancer in 2012 by gender and world regions.
Figure 2
Figure 2
(A) Correlation between age-standardised kidney cancer incidence (upper panel) and mortality (lower panel) and Human Development Index (HDI) (Male). (B) Correlation between age-standardised kidney cancer incidence (upper panel) and mortality (lower panel) and Human Development Index (HDI) (Female). (C) Correlation between age-standardised kidney cancer incidence (upper panel) and mortality (lower panel) and Human Development Index (HDI) (Both sex).
Figure 3
Figure 3
(A) Correlation between age-standardised kidney cancer incidence (upper panel) and mortality (lower panel) and Gross Domestic Product (GDP) (Male). (B) Correlation between age-standardised kidney cancer incidence (upper panel) and mortality (lower panel) and Gross Domestic Product (GDP) (Female). (C) Correlation between age-standardised kidney cancer incidence (upper panel) and mortality (lower panel) and Gross Domestic Product (GDP) (Both sex).
Figure 4
Figure 4
(A) The Average Annual Percent Change (AAPC) in the incidence of kidney cancer in male (left) and female (right) in the most recent 10 years. (B) The Average Annual Percent Change (AAPC) in the mortality of kidney cancer in male (left) and female (right) in the most recent 10 years.
See this image and copyright information in PMC

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