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Case Reports
. 2011 Apr;2(2):76-78.
doi: 10.4021/wjon292e. Epub 2011 Apr 9.

Kikuchi Fujimoto Disease, a Worrisome Presentation With a Reassuring Outcome

Zaher Oueida  1 , Ioana Chirca  1 , David Gallinson  2
Affiliations
Case Reports

Kikuchi Fujimoto Disease, a Worrisome Presentation With a Reassuring Outcome

Zaher Oueida et al. World J Oncol. 2011 Apr.

Abstract

We describe the case of a 27-year-old male with painful lymphadenopathy involving multiple sites. An excisional lymph node biopsy established the diagnosis of Kikuchi-Fujimoto disease (KFD) and the patient improved with supportive care only and did not have further episodes. This is a case of a rare, benign lymphadenitis, of unknown etiology. The histopathology proved the benign character of the lymphadenopathy and made the diagnosis clear, despite the nonspecific character of the clinical presentation. It is important to recognize the clinical and histopathological aspects of KFD in order to avoid unnecessary and sometimes harmful treatment, such as chemotherapy, when this disease is confounded with lymphoma.

Keywords: Fujimoto; Histiocytic; Kikuchi; Lymphadenitis.

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Conflict of interest statement

To the best of our knowledge, no conflict of interest, financial or other, exists.

References

    1. Kikuchi M. Lyphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytes: a clinicopathologic study. Nippon Kestsueki Gakkai Zasshi. 1972;35:379–380.
    1. Fujimoto Y, Kojima Y, Yamagushi K. Cervical subacute necrotizing lymphadenitis. A new clinicopathological entity. Naika. 1972;20:920–927.
    1. Good DJ, Gascoyne RD. Atypical lymphoid hyperplasia mimicking lymphoma. Hematol Oncol Clin North Am. 2009;23(4):729–745. doi: 10.1016/j.hoc.2009.04.005. - DOI - PubMed
    1. Yen A, Fearneyhough P, Raimer SS, Hudnall SD. EBV-associated Kikuchi’s histiocytic necrotizing lymphadenitis with cutaneous manifestations. J Am Acad Dermatol. 1997;36(2 Pt 2):342–346. doi: 10.1016/S0190-9622(97)80413-6. - DOI - PubMed
    1. Hudnall SD. Kikuchi-Fujimoto disease. Is Epstein-Barr virus the culprit? Am J Clin Pathol. 2000;113(6):761–764. - PubMed

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