Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Aug;2(4):175-180.
doi: 10.4021/wjon370w. Epub 2011 Aug 24.

Sarcomatoid Urothelial Carcinoma: A Single Cancer Center Experience

Jue Wang  1 , Caitlynn Gillaspie  1 , Rajesh Kunadharaju  1 , Geoffrey A Talmon  2 , Charles Enke  3
Affiliations

Sarcomatoid Urothelial Carcinoma: A Single Cancer Center Experience

Jue Wang et al. World J Oncol. 2011 Aug.

Abstract

Background: Sarcomatoid bladder cancer is a rare and aggressive variant of urothelial carcinoma.

Methods: A retrospective review of our experience in managing patients with sarcomatoid bladder cancer (SRBC) between 1997 and 2011 was performed to better define the behavior and outcomes of this disease.

Results: The median age of the patients was 63 years. All patients presented with high grade histology. Eighty-five percent of the patients presented with muscle invasive disease and fifty percent presented with stage IV carcinoma. Ten of 14 (71%) of patients underwent a cystectomy. Patients with SRBC was younger (P < 0.01), more commonly presented with higher grade histology (P < 0.01) and advanced stage disease (P < 0.01), in comparison with patients with Urothelial carcinoma (UC). At a median follow-up of 7 months (range 1.3 - 112), five (35.7%) patients have died in last follow-up. Two-year survival was 53.5%. Three patients with long term survival were reported.

Conclusions: Sarcomatoid bladder cancer is associated with poor prognosis. Multimodality therapy may improve these patients outcome.

Keywords: Cystectomy; Multimodality therapy; Outcome; Sarcomatoid bladder cancer.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Overall survival of 14 patients with sarcomatoid bladder cancer.
Figure 2
Figure 2
Overall survival of 14 patients with sarcomatoid bladder cancer according to stage (NMIBC: Nonmuscle invasive bladder cancer; MIBC: Muscle invasive bladder cancer).
See this image and copyright information in PMC

References

    1. Holtz F, Fox JE, Abell MR. Carcinosarcoma of the urinary bladder. Cancer. 1972;29(2):294–304. doi: 10.1002/1097-0142(197202)29:2<294::AID-CNCR2820290205>3.0.CO;2-V. - DOI - PubMed
    1. Young RH. Carcinosarcoma of the urinary bladder. Cancer. 1987;59(7):1333–1339. doi: 10.1002/1097-0142(19870401)59:7<1333::AID-CNCR2820590717>3.0.CO;2-N. - DOI - PubMed
    1. Giannopoulos A, Alivizatos G, Kyriakou V, Mitropoulos D, Dimopoulos MA. Carcinosarcoma of the bladder. Br J Urol. 1991;67(1):106–107. doi: 10.1111/j.1464-410X.1991.tb15086.x. - DOI - PubMed
    1. Lahoti C, Schinella R, Rangwala AF, Lee M, Mizrachi H. Carcinosarcoma of urinary bladder: report of 5 cases with immunohistologic study. Urology. 1994;43(3):389–393. doi: 10.1016/0090-4295(94)90087-6. - DOI - PubMed
    1. Lopez-Beltran A, Pacelli A, Rothenberg HJ, Wollan PC, Zincke H, Blute ML, Bostwick DG. Carcinosarcoma and sarcomatoid carcinoma of the bladder: clinicopathological study of 41 cases. J Urol. 1998;159(5):1497–1503. doi: 10.1097/00005392-199805000-00023. - DOI - PubMed

LinkOut - more resources