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Case Reports
. 2012 Apr;3(2):83-86.
doi: 10.4021/wjon442w. Epub 2012 Apr 23.

Brain Metastasis From Prostate Adenocarcinoma: Case Report and Review of Literature

Graziano Taddei  1   2 , Sara Marzi  2 , Gino Coletti  3 , Danilo De Paulis  2 , Alessandro Ricci  2 , Renato J Galzio  2   4
Affiliations
Case Reports

Brain Metastasis From Prostate Adenocarcinoma: Case Report and Review of Literature

Graziano Taddei et al. World J Oncol. 2012 Apr.

Abstract

It is rare for prostate carcinoma to metastasize to the central nervous system. It often represents a terminal event with death in one year frequently due to the advanced systemic disease. Starting by a case report, we also reviewed the relevant literature to focus on this uncommon entity from epidemiology to clinical manifestation and therapeutic strategies. In this article, a case of multiple brain prostate metastasis is reported and a review of relevant literature is also discussed. Treatments available for intracranial metastasis include neurosurgery, external beam radiation and hormonal manipulation. Surgery associated with whole brain radiotherapy seems to be effective in the control of brain lesions both relieving neurological symptoms and prolonging survival, even if prognosis remains dismal. From this case, we concluded that brain metastasis from prostate carcinoma is a rare, terminal event with death in one year frequently due to the advanced systemic disease. A better understanding of the biology of prostate carcinoma will help clarify the basis for its metastasis to the brain.

Keywords: Brain metastasis; Prostate adenocarcinoma; Small cells prostate carcinoma.

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Conflict of interest statement

The authors do not have any conflict of interest or financial arrangement.

Figures

Figure 1
Figure 1
Brain MR with gadolinium showing the six distinct intraparenchymal lesions.
Figure 2
Figure 2
Post-operative brain TC.
Figure 3
Figure 3
Histologic patterns: immunohistochemical stain for PSA (A) and PSMA (B).
See this image and copyright information in PMC

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