Rectal Plasmablastic Lymphoma in HIV/AIDS: Two Cases

Abstract

Plasmablastic lymphoma is an aggressive variant of large B-cells lymphoma in which the infection by Human Immunodeficiency Virus and Epstein-Barr herpesvirus are involved. This recently denominated neoplasia has a special tropism through the oral cavity. However, its presence has been reported in the digestive tract, abdominal cavity and retroperitoneum. We describe two Human Immunodeficiency Virus infected patient cases with rectal presentation of PL in the HIV service of the Hospital Civil de Guadalajara.

Keywords: AIDS; HAART; Plasmablastic lymphoma; Rectal tumor.

Figure 1

Case One. A) Pelvis CT where evidences rectal tumor with perirectal fascia engrossed. B) Tumor with extensive necrosis in the right lower quadrant, viable zones of monotonous, slightly cohesive, moderately pleomorphic plamacytoids showing a paranuclear light halo. HE (400 ×). C) Immunreactivity for CD-20 cytoplasmatic and membranous (400 ×). D) Immunohistochemistry for CD-138 membranous and cytoplasmatic (400 ×).

Figure 2

Case two. A) Plasmacytoid cells with eccentric nucleus and a light paranuclear zone. Cells are slightly cohesive and some nucleus are wheel-shaped. It is also evident the presence of a fibrin microthrombi. HE (400X). B) Abundant bacillus colonization. Bacteria are black stained. Whartin Starry (100X). C) Membrane immunoreactivity to CD-45 (400X). D) Membrane an cytoplasmic immunoreactivity to CD-138.