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Case Reports
. 2017:2017:7290945.
doi: 10.1155/2017/7290945. Epub 2017 Sep 25.

Upper Limb Deep Vein Thrombosis in Patient with Hemophilia A and Heterozygosity for Prothrombin G20210A: A Case Report and Review of the Literature

Fares Darawshy  1 , Yosef Kalish  2 , Issam Hendi  1 , Ayman Abu Rmelieh  1 , Tawfik Khoury  1
Affiliations
Case Reports

Upper Limb Deep Vein Thrombosis in Patient with Hemophilia A and Heterozygosity for Prothrombin G20210A: A Case Report and Review of the Literature

Fares Darawshy et al. Case Rep Hematol. 2017.

Abstract

Deep vein thrombosis (DVT) is a rare disease in patients with hemophilia A. We report a case of 22-year-old male with severe hemophilia A who presented to the emergency room with 5-day history of right arm pain that was attributed initially to bleeding event. In the absence of external signs of bleeding or hematoma and normal hemoglobin level, we suspected an underlying DVT. Doppler ultrasonography of the right upper limb revealed thrombosis of the subclavian vein and this was confirmed by CT venography. The d-dimer level was normal and investigations for prothrombotic state revealed heterozygosity for prothrombin G20210A mutation. Treatment with factor VIII and low molecular weight heparin led to successful resolution and marked improvement of his clinical condition.

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Figures

Figure 1
Figure 1
Doppler US and CT scan showing DVT in the right subclavian vein. Arrows refer to deep vein thrombosis.
See this image and copyright information in PMC

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