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Avian Influenza A(H7N2) Virus in Human Exposed to Sick Cats, New York, USA, 2016

Atanaska Marinova-Petkova et al. Emerg Infect Dis. 2017 Dec.

Abstract

An outbreak of influenza A(H7N2) virus in cats in a shelter in New York, NY, USA, resulted in zoonotic transmission. Virus isolated from the infected human was closely related to virus isolated from a cat; both were related to low pathogenicity avian influenza A(H7N2) viruses detected in the United States during the early 2000s.

Keywords: A(H7N2); Avian influenza; H7N2; New York; United States; animal shelter; cat-to-human transmission; human infection with H7N2; influenza; interspecies transmission; respiratory infections; viruses.

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Figures

Figure 1
Figure 1
Receptor binding specificity of A/New York/108/2016 (H7N2) influenza virus isolated from a human who experienced influenza-like illness after exposure to sick domestic cats at an animal shelter in New York, NY, USA, 2016. Figure indicates glycan microarray analysis. Colored bars represent glycans that contain α-2,3 sialic acid (SA) (blue), α-2,6 SA (red), α-2,3/α-2,6 mixed SA (purple), N-glycolyl SA (green), α-2,8 SA (brown), β-2,6 and 9-O-acetyl SA (yellow), and non-SA (gray). Error bars reflect SE in the signal for 6 independent replicates on the array. RFI, relative fluorescence intensity.
Figure 2
Figure 2
Receptor binding specificity of A/New York/108/2016 (H7N2) influenza virus isolated from a human who experienced influenza-like illness after exposure to sick domestic cats at an animal shelter in New York, NY, USA, 2016. Figure shows A/New York/108/2016 hemagglutinin (HA) monomer structure. HA1 is shown in gray, HA2 in light purple, amino acid changes in comparison with reference virus A/turkey/Virginia/4529/2002 (H7N2) in red. On the cartoon view (left), all amino acid changes in the HA protein are labeled. The location of the receptor binding site (blue circle) includes the 120-loop and the 180-helix. The 220-loop is missing due to deletion of amino acids 212–219 in the mature HA protein (H7 numbering). On the surface model (right), only amino acid substitutions adjacent to the antigenic sites and receptor binding site are labeled. Antigenic site B is yellow, antigenic site C green.
See this image and copyright information in PMC

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