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Review
. 2018 Feb;37(2):63-69.
doi: 10.1089/dna.2017.4033. Epub 2017 Nov 17.

Repurposing of Kinase Inhibitors as Broad-Spectrum Antiviral Drugs

Stanford Schor  1   2 , Shirit Einav  1   2
Affiliations
Review

Repurposing of Kinase Inhibitors as Broad-Spectrum Antiviral Drugs

Stanford Schor et al. DNA Cell Biol. 2018 Feb.

Abstract

The high cost of drug development and the narrow spectrum of coverage typically provided by direct-acting antivirals limit the scalability of this antiviral approach. This review summarizes progress and challenges in the repurposing of approved kinase inhibitors as host-targeted broad-spectrum antiviral therapies.

Keywords: antiviral drugs; broad-spectrum antivirals; kinase inhibitors; repurposing.

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Conflict of interest statement

No competing financial interests exist.

Figures

<b>FIG. 1.</b>
FIG. 1.
Approved kinase inhibitors with broad-spectrum antiviral activity. Examples of classes of kinase inhibitors with broad-spectrum antiviral activity and the specific steps of the viral life cycle they target (if known) are denoted in colored boxes. Blunt arrows connect these compounds to the corresponding targeted cellular process thought to mediate their antiviral effect.
See this image and copyright information in PMC

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