Risky Business: The Circuits that Impact Stress-Induced Decision-Making
- PMID: 29149614
- DOI: 10.1016/j.cell.2017.11.004
Risky Business: The Circuits that Impact Stress-Induced Decision-Making
Abstract
How does stress promote risky decision-making? Friedman et al. find that stress disrupts inhibition of striatal circuits by prefrontal cortex, rendering animals insensitive to potential losses. This may help explain how stress contributes to substance abuse and how it can disinhibit automatic behaviors, such as tics in Tourette syndrome.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
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Chronic Stress Alters Striosome-Circuit Dynamics, Leading to Aberrant Decision-Making.Cell. 2017 Nov 16;171(5):1191-1205.e28. doi: 10.1016/j.cell.2017.10.017. Cell. 2017. PMID: 29149606 Free PMC article.
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