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Randomized Controlled Trial
. 2017 Nov 17;17(1):71.
doi: 10.1186/s12902-017-0221-3.

Vitamin D, parathyroid hormone and metabolic syndrome - the PORMETS study

Luís Raposo  1   2 , Sandra Martins  3   4 , Daniela Ferreira  3 , João Tiago Guimarães  3   4   5 , Ana Cristina Santos  6   3   7
Affiliations
Randomized Controlled Trial

Vitamin D, parathyroid hormone and metabolic syndrome - the PORMETS study

Luís Raposo et al. BMC Endocr Disord. .

Abstract

Background: Vitamin D (VitD) and parathyroid hormone (PTH) play important roles in calcium metabolism and skeletal homeostasis. Estimates of the VitD status in several European countries show large variations between them. In addition, no national population-based estimate has been published. VitD and PTH may also play important roles in cardiovascular risk, which has been suggested to be associated with metabolic syndrome (MetS) and is very prevalent in Portugal. The goal of our study was to evaluate the prevalence of hypovitaminosis D and its determinants as well as PTH serum level determinants and associations of the 25-hydroxyvitamin D and PTH serum levels with MetS and its individual components in a sample of the Portuguese mainland population.

Methods: PORMETS is a national cross-sectional study that includes a total sample of 4095 adults. A subsample, including 500 participants, was randomly selected for the present study. A structured questionnaire was administered to collect information on personal medical histories and socio-demographic and behavioral characteristics. Blood pressure and anthropometrics measurements were performed. Fasting venous samples were collected and PTH and 25-hydroxyvitamin D were measured. VitD adequacy was classified according to the Institute of Medicine, and MetS was classified according to the Joint Interim Statement recommendations. Multiple linear regression and unconditional logistic regression models were used to estimate the associations between the levels of PTH and 25-hydroxyvitamin D and with MetS and its individual components.

Results: The prevalence of VitD deficiency was 37.7%, and MetS was present in 191 participants (38.4%). The serum PTH levels showed a positive association (OR: 1.014; 95%CI: 1.002, 1.026) with the waist circumference component of MetS. The serum 25-hydroxyvitamin D levels were negatively associated with MetS (OR: 0.957; 95%CI: 0.922, 0.993) as well as with its blood pressure (OR: 0.949; 95%CI: 0.912, 0.987) and triglycerides (OR: 0.930; 95%CI: 0.892, 0.969) components.

Conclusion: This study showed a high national prevalence of hypovitaminosis D. The PTH levels showed a significant positive association with the WC component of MetS, and the VitD levels were negatively associated with the BP and triglycerides components as well as with the MetS.

Keywords: Cardiovascular risk; Functional hypoparathyroidism; Metabolic syndrome; PTH; Portugal; Prevalence; Vitamin D.

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Conflict of interest statement

Ethics approval and consent to participate

All the Portuguese Regional Health Administrations, the Ethics Committee of the São João Hospital E.P.E. and the Portuguese Data Protection Authority, approved PORMETS. The Clinical Director of each health care center also provided authorization and all participants gave their written informed consent. The Ethics Committee of Centro Hospitalar São João (Porto, Portugal) approved the study in the 27th February 2007 and the authorization from the Portuguese Data Protection Authority is CNDP: 1053/2007.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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