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Review
. 2018 Feb;44(1):89-111.
doi: 10.1016/j.rdc.2017.09.005.

Gastrointestinal and Hepatic Disease in Rheumatoid Arthritis

Affiliations
Review

Gastrointestinal and Hepatic Disease in Rheumatoid Arthritis

Ethan Craig et al. Rheum Dis Clin North Am. 2018 Feb.

Abstract

Gastrointestinal (GI) manifestations of rheumatoid arthritis (RA) are rare, but can be impactful for patients. Some GI processes are directly related to RA, whereas others may be sequelae of treatment or caused by concomitant autoimmune diseases. This article discusses the role of the GI tract in RA pathogenesis; the presentation, epidemiology, and diagnosis of RA-related GI manifestations; concomitant GI autoimmune diseases that may affect those with RA; and GI side effects of RA treatment. The importance of appropriately considering conditions unrelated to RA in the differential diagnosis when evaluating new GI symptoms in patients with RA is noted.

Keywords: Antirheumatic medications (DMARDs); Gastrointestinal disease; Hepatic disease; Rheumatoid arthritis.

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Figures

Figure 1
Figure 1
An overview of digestive and hepatic complications from rheumatoid arthritis, its treatment, and related disorders

References

    1. Ciccia F, Ferrante A, Guggino G, Triolo G. The role of the gastrointestinal tract in the pathogenesis of rheumatic diseases. Best Pract Res Clin Rheumatol. 2016;30(5):889–900. - PubMed
    1. Chen K, Liu J, Cao X. Regulation of type I interferon signaling in immunity and inflammation: a comprehensive review. J Autoimmun. 2017 In press. - PubMed
    1. Helmick CG, Felson DT, Lawrence RC, et al. Estimates of the Prevalence of Arthritis and Other Rheumatic Conditions in the United States Part I. Arthritis Rheumatol. 2008;58(1):15–25. - PubMed
    1. Crowson CS, Matteson EL, Myasoedova E, et al. The lifetime risk of adult-onset rheumatoid arthritis and other inflammatory autoimmune rheumatic diseases. Arthritis Rheumatol. 2011;63(3):633–639. - PMC - PubMed
    1. Kurkó J, Besenyei T, Laki J, Glant TT, Mikecz K, Szekanecz Z. Genetics of rheumatoid arthritis - a comprehensive review. Clin Rev Allergy Immunol. 2013;45(2):170–179. - PMC - PubMed

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