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Review
. 2018 Jan;34(1):139-152.
doi: 10.1016/j.ccc.2017.08.010. Epub 2017 Oct 12.

Biomarkers in Sepsis

Tjitske S R van Engelen  1 , Willem Joost Wiersinga  2 , Brendon P Scicluna  3 , Tom van der Poll  2
Affiliations
Review

Biomarkers in Sepsis

Tjitske S R van Engelen et al. Crit Care Clin. 2018 Jan.

Abstract

A biomarker is a characteristic by which a (patho)physiologic process can be identified. Biomarkers can be of diagnostic value (to discriminate infection from noninfectious conditions or to determine the causative pathogen), of prognostic value (assigning risk profiles and predict outcome), and in the future may be of theranostic value (aid in selection and monitoring of therapy). Systems biology provides a promising tool for the discovery of novel biomarkers. Biomarkers can be the key to personalized targeted treatment in the future clinical management of sepsis.

Keywords: Biomarkers; Diagnosis; Omics technologies; Procalcitonin; Prognosis; Sepsis; Transcriptomics.

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