Improving Long-Term Outcomes After Sepsis

doi:10.1016/j.ccc.2017.08.013

Review

. 2018 Jan;34(1):175-188.

doi: 10.1016/j.ccc.2017.08.013. Epub 2017 Oct 5.

Improving Long-Term Outcomes After Sepsis

Hallie C Prescott¹, Deena Kelly Costa²

Affiliations

¹ Department of Internal Medicine, University of Michigan, VA Center for Clinical Management Research, HSR&D Center of Innovation, North Campus Research Center, 2800 Plymouth Road, Building 16, 341E, Ann Arbor, MI 48109-2800, USA. Electronic address: hprescot@med.umich.edu.
² Department of Systems, Populations & Leadership, School of Nursing, University of Michigan, 400 North Ingalls Street #4351, Ann Arbor, MI 48109-5482, USA.

PMID: 29149939
PMCID: PMC5708876
DOI: 10.1016/j.ccc.2017.08.013

Review

Improving Long-Term Outcomes After Sepsis

Hallie C Prescott et al. Crit Care Clin. 2018 Jan.

. 2018 Jan;34(1):175-188.

doi: 10.1016/j.ccc.2017.08.013. Epub 2017 Oct 5.

Authors

Hallie C Prescott¹, Deena Kelly Costa²

Affiliations

¹ Department of Internal Medicine, University of Michigan, VA Center for Clinical Management Research, HSR&D Center of Innovation, North Campus Research Center, 2800 Plymouth Road, Building 16, 341E, Ann Arbor, MI 48109-2800, USA. Electronic address: hprescot@med.umich.edu.
² Department of Systems, Populations & Leadership, School of Nursing, University of Michigan, 400 North Ingalls Street #4351, Ann Arbor, MI 48109-5482, USA.

PMID: 29149939
PMCID: PMC5708876
DOI: 10.1016/j.ccc.2017.08.013

Abstract

Although acute survival from sepsis has improved in recent years, a large fraction of sepsis survivors experience poor long-term outcomes. In particular, sepsis survivors have high rates of weakness, cognitive impairment, hospital readmission, and late death. To improve long-term outcomes, in-hospital care should focus on early, effective treatment of sepsis; minimization of delirium, distress, and immobility; and preparing patients for hospital discharge. In the posthospital setting, medical care should focus on addressing new disability and preventing medical deterioration, providing a sustained period out of the hospital to allow for recovery.

Keywords: Anxiety; Cognitive impairment; Depression; Physical disability; Re-hospitalization; Stress.

Published by Elsevier Inc.

PubMed Disclaimer

Conflict of interest statement

Disclosures: This work does not represent the position or policy of the US government of the Department of Veteran’s Affairs. The authors have no financial conflicts of interest.

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References

1. Kaukonen KM, Bailey M, Suzuki S, Pilcher D, Bellomo R. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000–2012. JAMA. 2014;311:1308–1316. - PubMed
1. Prescott HC, Kepreos KM, Wiitala WL, Iwashyna TJ. Temporal Changes in the Influence of Hospitals and Regional Healthcare Networks on Severe Sepsis Mortality. Crit Care Med. 2015;43:1368–1374. - PMC - PubMed
1. Iwashyna TJ, Speelmon EC. Advancing a Third Revolution in Critical Care. Am J Respir Crit Care Med. 2016;194:782–783. - PubMed
1. Iwashyna TJ, Ely EW, Smith DM, Langa KM. Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA. 2010;304:1787–1794. - PMC - PubMed
1. Prescott HC, Osterholzer JJ, Langa KM, Angus DC, Iwashyna TJ. Late mortality after sepsis: propensity matched cohort study. BMJ. 2016;353:i2375–i2375. - PMC - PubMed

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[1] Kaukonen KM, Bailey M, Suzuki S, Pilcher D, Bellomo R. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000–2012. JAMA. 2014;311:1308–1316. - PubMed

[2] Kaukonen KM, Bailey M, Suzuki S, Pilcher D, Bellomo R. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000–2012. JAMA. 2014;311:1308–1316. - PubMed

[3] Prescott HC, Kepreos KM, Wiitala WL, Iwashyna TJ. Temporal Changes in the Influence of Hospitals and Regional Healthcare Networks on Severe Sepsis Mortality. Crit Care Med. 2015;43:1368–1374. - PMC - PubMed

[4] Prescott HC, Kepreos KM, Wiitala WL, Iwashyna TJ. Temporal Changes in the Influence of Hospitals and Regional Healthcare Networks on Severe Sepsis Mortality. Crit Care Med. 2015;43:1368–1374. - PMC - PubMed

[5] Iwashyna TJ, Speelmon EC. Advancing a Third Revolution in Critical Care. Am J Respir Crit Care Med. 2016;194:782–783. - PubMed

[6] Iwashyna TJ, Speelmon EC. Advancing a Third Revolution in Critical Care. Am J Respir Crit Care Med. 2016;194:782–783. - PubMed

[7] Iwashyna TJ, Ely EW, Smith DM, Langa KM. Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA. 2010;304:1787–1794. - PMC - PubMed

[8] Iwashyna TJ, Ely EW, Smith DM, Langa KM. Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA. 2010;304:1787–1794. - PMC - PubMed

[9] Prescott HC, Osterholzer JJ, Langa KM, Angus DC, Iwashyna TJ. Late mortality after sepsis: propensity matched cohort study. BMJ. 2016;353:i2375–i2375. - PMC - PubMed

[10] Prescott HC, Osterholzer JJ, Langa KM, Angus DC, Iwashyna TJ. Late mortality after sepsis: propensity matched cohort study. BMJ. 2016;353:i2375–i2375. - PMC - PubMed

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Improving Long-Term Outcomes After Sepsis

Affiliations

Improving Long-Term Outcomes After Sepsis

Authors

Affiliations

Abstract

Conflict of interest statement

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Cited by

References

Publication types

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Grants and funding

LinkOut - more resources

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Medical