License to kill: IFN-λ regulates antifungal activity of neutrophils

Daniel Schnepf^{1

2}, Peter Staeheli³

Affiliations

¹ Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany.
² Spemann Graduate School of Biology and Medicine, Albert Ludwigs University Freiburg, Freiburg, Germany.
³ Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany. peter.staeheli@uniklinik-freiburg.de.

Comment

Daniel Schnepf et al. Sci Immunol. 2017.

. 2017 Nov 17;2(17):eaap9614.

doi: 10.1126/sciimmunol.aap9614. Epub 2017 Nov 17.

Daniel Schnepf^{1

2}, Peter Staeheli³

¹ Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany.
² Spemann Graduate School of Biology and Medicine, Albert Ludwigs University Freiburg, Freiburg, Germany.
³ Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany. peter.staeheli@uniklinik-freiburg.de.

Abstract

Interferon-λ mediates antifungal immunity by stimulating neutrophils to generate reactive oxygen species.

Type III interferon is a critical regulator of innate antifungal immunity.
Espinosa V, Dutta O, McElrath C, Du P, Chang YJ, Cicciarelli B, Pitler A, Whitehead I, Obar JJ, Durbin JE, Kotenko SV, Rivera A. Espinosa V, et al. Sci Immunol. 2017 Oct 6;2(16):eaan5357. doi: 10.1126/sciimmunol.aan5357. Sci Immunol. 2017. PMID: 28986419 Free PMC article.