Re-educating immunity in respiratory allergies: the potential for hematopoietic stem cell-mediated gene therapy

Jeremy F Brooks¹, Janet M Davies^{2

3}, James W Wells¹, Raymond J Steptoe⁴

Affiliations

¹ The University of Queensland, Translational Research Institute, University of Queensland Diamantina Institute, Level 6, 37 Kent Street, Woolloongabba, Queensland, 4102, Australia.
² School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
³ Office of Research, Metro North Hospital and Health Service, Herston, Brisbane, Queensland, Australia.
⁴ The University of Queensland, Translational Research Institute, University of Queensland Diamantina Institute, Level 6, 37 Kent Street, Woolloongabba, Queensland, 4102, Australia. r.steptoe@uq.edu.au.

PMID: 29150718
DOI: 10.1007/s00109-017-1611-8

Review

Re-educating immunity in respiratory allergies: the potential for hematopoietic stem cell-mediated gene therapy

Jeremy F Brooks et al. J Mol Med (Berl). 2018 Jan.

. 2018 Jan;96(1):21-30.

doi: 10.1007/s00109-017-1611-8. Epub 2017 Nov 17.

Authors

Jeremy F Brooks¹, Janet M Davies^{2

3}, James W Wells¹, Raymond J Steptoe⁴

Affiliations

¹ The University of Queensland, Translational Research Institute, University of Queensland Diamantina Institute, Level 6, 37 Kent Street, Woolloongabba, Queensland, 4102, Australia.
² School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
³ Office of Research, Metro North Hospital and Health Service, Herston, Brisbane, Queensland, Australia.
⁴ The University of Queensland, Translational Research Institute, University of Queensland Diamantina Institute, Level 6, 37 Kent Street, Woolloongabba, Queensland, 4102, Australia. r.steptoe@uq.edu.au.

PMID: 29150718
DOI: 10.1007/s00109-017-1611-8

Abstract

Respiratory allergies represent a significant disease burden worldwide affecting up to 300 million people globally. Medication and avoidance of known triggers do not address the underlying pathology. Traditional immunotherapies for allergy aim to reinstate immune homeostasis but require years of treatment and have poor long-term efficacy. Novel approaches, such as gene-engineered hematopoietic stem cell transplantation, induce profound antigen-specific tolerance in autoimmunity. Recent evidence shows this approach may also have therapeutic utility for allergy. Here, we review the mechanisms of antigen-specific tolerance and the potential of stem cell-mediated gene therapy to induce tolerance in allergic respiratory diseases.

Keywords: Allergy; Autoimmunity; Gene therapy; Tolerance.

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References

1. Nat Immunol. 2016 Dec;17(12):1436-1446 - PubMed
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1. J Immunol. 1967 May;98(5):982-90 - PubMed
1. Am J Transplant. 2002 Jul;2(6):501-9 - PubMed

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Re-educating immunity in respiratory allergies: the potential for hematopoietic stem cell-mediated gene therapy

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Re-educating immunity in respiratory allergies: the potential for hematopoietic stem cell-mediated gene therapy

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