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Comment
. 2018 Mar;15(3):284-285.
doi: 10.1038/cmi.2017.108. Epub 2017 Nov 20.

IL-1α in acetaminophen toxicity: a sterile danger signal

Arvin Iracheta-Vellve  1 , Gyongyi Szabo  1
Affiliations
Comment

IL-1α in acetaminophen toxicity: a sterile danger signal

Arvin Iracheta-Vellve et al. Cell Mol Immunol. 2018 Mar.
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
IL-1α signaling in acetaminophen-induced liver injury. Acetaminophen overdose results in hepatocyte damage and DAMP release, which causes IL-1α release by Kupffer cells in a TLR4/MyD88-dependent manner. IL-1α then signals to neutrophils through IL-1R and its adaptor, MyD88, potentiating liver injury and the inflammatory cascade. DAMP, damage-associated molecular pattern.
See this image and copyright information in PMC

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