Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017;90(4):396-400.
doi: 10.15386/cjmed-781. Epub 2017 Oct 20.

Infantile hemangiomas: a 7-year experience of a single-center

Mădălina Bota  1 , Gheorghe Popa  1 , Cristina Lucia Blag  1 , Daniel-Corneliu Leucuta  2 , Alexandru Tătaru  3
Affiliations

Infantile hemangiomas: a 7-year experience of a single-center

Mădălina Bota et al. Clujul Med. 2017.

Abstract

Objectives: The aim of the study was to describe the historical and clinical characteristics of hemangiomas in a series of cases of our clinic.

Methods: This is a retrospective study of 36 patients with infantile hemangiomas consulted in our clinic.

Results: We had 14 multiple hemangiomas, and 1 kaposiform hemangioendothelioma. Almost two-thirds involved the cephalic extremity, and 76% of the cases were treated. Pregnancy risk factors included prematurity, low-birth weight and respiratory distress syndrome. Propranolol was used in 22 cases, followed by prednisone in 3 cases. Vincristine and interferon were used as associated therapies or as second line therapies. Two hemangiomas had complications, one ulceration and a Kasabach-Merritt syndrome. All the patients had a good evolution.

Conclusions: Our study results regarding the involvement of pregnancy and birth risk factors in developing infantile hemangiomas is similar to literature data. The majority of patients had at least one risk factor suggesting that at least one trigger to develop an infantile hemangioma is necessary. Our study shows that the cephalic extremity is mostly involved, and because of its potential complications they are most likely to be treated. The study shows that propranolol is the leading treatment option with few and mild side effects.

Keywords: evolution; infantile hemangioma; risk factors; treatment.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The aspect of the lesions of the Kasabach Merritt case at the diagnosis. The image shows the swelling of the lower left limb, with red-purple color and edema due to compression, a typical aspect of Kasabach-Merritt syndrome.
Figure 2
Figure 2
The aspect of lesions of the Kasabach Merritt after treatment. The image above outlines the improvement after 1 year of treatment of the infant with Kasabach Merritt syndrome. The swelling has withdrawn, there is no edema of the limb. A small area of residual lesions can still be seen on the interior side of the leg.
See this image and copyright information in PMC

References

    1. Léauté-Labrèze C. [Infantile hemangioma: update and treatment]. Arch Pediatr. 2013;20(5):517–522. - PubMed
    1. Marqueling AL, Oza V, Frieden IJ, Puttgen KB. Propranolol and infantile hemangiomas four years later: a systematic review. Pediatr Dermatol. 2013;30(2):182–191. - PubMed
    1. Chen XD, Ma G, Huang JL, Chen H, Jin YB, Ye XX, et al. Serum-level changes of vascular endothelial growth factor in children with infantile hemangioma after oral propranolol therapy. Pediatr Dermatol. 2013;30(5):549–553. - PubMed
    1. Hemangioma Investigator Group. Haggstrom AN, Drolet BA, Baselga E, Chamlin SL, Garzon MC, et al. Prospective study of infantile hemangiomas: demographic, prenatal, and perinatal characteristics. J Pediatr. 2007;150(3):291–294. - PubMed
    1. Chen XD, Ma G, Chen H, Ye XX, Jin YB, Lin XX. Maternal and perinatal risk factors for infantile hemangioma: a case-control study. Pediatr Dermatol. 2013;30(4):457–461. - PubMed

LinkOut - more resources