. 2017 Jul 29;8(50):87073-87085.

doi: 10.18632/oncotarget.19692. eCollection 2017 Oct 20.

Development of a population-based cancer case-control study in southern china

Weimin Ye¹, Ellen T Chang^{2

3}, Zhiwei Liu¹, Qing Liu^{4

5}, Yonglin Cai^{6

7}, Zhe Zhang^{8

9}, Guomin Chen¹⁰, Qi-Hong Huang¹¹, Shang-Hang Xie^{4

5}, Su-Mei Cao^{4

5}, Jian-Yong Shao⁵, Wei-Hua Jia⁵, Yuming Zheng^{6

7}, Jian Liao¹², Yufeng Chen⁹, Longde Lin⁹, Liming Liang^{13

14}, Ingemar Ernberg¹⁵, Thomas L Vaughan^{16

17}, Guangwu Huang^#^{8

9}, Yi Zeng^#¹⁰, Yi-Xin Zeng^#^{5

18}, Hans-Olov Adami^#^{1

13}

Affiliations

¹ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
² Exponent, Inc., Health Sciences Practice, Menlo Park, CA, USA.
³ Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA.
⁴ Department of Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, China.
⁵ State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
⁶ Department of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, China.
⁷ Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism, Wuzhou, China.
⁸ Department of Otolaryngology-Head & Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
⁹ Key Laboratory of High-Incidence-Tumor Prevention & Treatment (Guangxi Medical University), Ministry of Education, Nanning, China.
¹⁰ State Key Laboratory for Infectious Diseases Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
¹¹ Sihui Cancer Institute, Sihui, China.
¹² Cangwu Institute for Nasopharyngeal Carcinoma Control and Prevention, Wuzhou, China.
¹³ Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.
¹⁴ Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA, USA.
¹⁵ Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
¹⁶ Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
¹⁷ Department of Epidemiology, University of Washington, Seattle, WA, USA.
¹⁸ Beijing Hospital, Beijing, China.

^# Contributed equally.

PMID: 29152064
PMCID: PMC5675616
DOI: 10.18632/oncotarget.19692

Development of a population-based cancer case-control study in southern china

Weimin Ye et al. Oncotarget. 2017.

. 2017 Jul 29;8(50):87073-87085.

doi: 10.18632/oncotarget.19692. eCollection 2017 Oct 20.

Authors

Affiliations

¹ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
² Exponent, Inc., Health Sciences Practice, Menlo Park, CA, USA.
³ Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA.
⁴ Department of Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, China.
⁵ State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
⁶ Department of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, China.
⁷ Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism, Wuzhou, China.
⁸ Department of Otolaryngology-Head & Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
⁹ Key Laboratory of High-Incidence-Tumor Prevention & Treatment (Guangxi Medical University), Ministry of Education, Nanning, China.
¹⁰ State Key Laboratory for Infectious Diseases Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
¹¹ Sihui Cancer Institute, Sihui, China.
¹² Cangwu Institute for Nasopharyngeal Carcinoma Control and Prevention, Wuzhou, China.
¹³ Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.
¹⁴ Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA, USA.
¹⁵ Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
¹⁶ Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
¹⁷ Department of Epidemiology, University of Washington, Seattle, WA, USA.
¹⁸ Beijing Hospital, Beijing, China.

^# Contributed equally.

PMID: 29152064
PMCID: PMC5675616
DOI: 10.18632/oncotarget.19692

Abstract

With its population of over 1.3 billion persons, China offers abundant opportunities to discover causes of disease. However, few rigorous population-based case-control studies have as yet been conducted in mainland China. We conducted a population-based case-control study of nasopharyngeal carcinoma in Guangdong Province and Guangxi Autonomous Region. We collected questionnaires and biospecimens from incident cases recruited between March 2010 and December 2013, and population-based controls between November 2010 and November 2014. Preparatory activities prior to subject enrollment required approximately 18 months. We enrolled a total of 2554 NPC cases and 2648 controls. Among all identified cases, 83.8% participated. For the participating cases, the median time between diagnosis and interview was 2 days. Among all contacted controls, 82.7% participated. From the enrolled cases, we collected 2518 blood specimens (provided by 98.6% of eligible cases), 2350 saliva specimens (92.0%), 2514 hair specimens (98.4%), and 2507 toenail/fingernail specimens (98.2%). From the enrolled controls, we collected 2416 blood specimens (91.2%), 2505 saliva specimens (94.6%), 2517 hair specimens (95.1%), and 2514 toenail/fingernail specimens (94.9%). We demonstrate that population-based epidemiologic research can successfully be conducted in southern China. The study protocols, databases, and biobank will serve as an extraordinarily valuable resource for testing future etiologic hypotheses.

Keywords: case-control study; china; nasopharyngeal carcinoma.

PubMed Disclaimer

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interest.

Figures

**Figure 1. Timeline for meetings and training workshops**
Schematic showing the timeline of annual research meetings, field work meetings, and interviewer training workshops held between 2008 and 2013.

**Figure 2. Box plot of days (in log10 scale) between diagnosis and interview by residential area among cases**
The day of zero was set as one in log scale.

**Figure 3. Geographic locations of participating hospitals and cancer research institutions**
GMU, Guangxi Medical University; NPC, nasopharyngeal carcinoma.

See this image and copyright information in PMC

Cited by

Environmental Factors for Epstein-Barr Virus Reactivation in a High-Risk Area of Nasopharyngeal Carcinoma: A Population-Based Study.
Chen Y, Chang ET, Liu Q, Cai Y, Zhang Z, Chen G, Huang QH, Xie SH, Cao SM, Jia WH, Zheng Y, Li Y, Lin L, Ernberg I, Huang G, Zeng YX, Adami HO, Ye W. Chen Y, et al. Open Forum Infect Dis. 2022 Mar 15;9(5):ofac128. doi: 10.1093/ofid/ofac128. eCollection 2022 May. Open Forum Infect Dis. 2022. PMID: 35450082 Free PMC article.
Reproductive history and risk of nasopharyngeal carcinoma: A population-based case-control study in southern China.
Feng RM, Chang ET, Liu Z, Liu Q, Cai Y, Zhang Z, Chen G, Huang QH, Xie SH, Cao SM, Zhang Y, Yun J, Jia WH, Zheng Y, Liao J, Chen Y, Lin L, Ernberg I, Huang G, Zeng Y, Zeng YX, Adami HO, Ye W. Feng RM, et al. Oral Oncol. 2019 Jan;88:102-108. doi: 10.1016/j.oraloncology.2018.11.025. Epub 2018 Nov 23. Oral Oncol. 2019. PMID: 30616779 Free PMC article.
A novel causal model for nasopharyngeal carcinoma.
Chang ET, Ye W, Ernberg I, Zeng YX, Adami HO. Chang ET, et al. Cancer Causes Control. 2022 Jul;33(7):1013-1018. doi: 10.1007/s10552-022-01582-x. Epub 2022 Apr 19. Cancer Causes Control. 2022. PMID: 35441278
Subspecies Niche Specialization in the Oral Microbiome Is Associated with Nasopharyngeal Carcinoma Risk.
Debelius JW, Huang T, Cai Y, Ploner A, Barrett D, Zhou X, Xiao X, Li Y, Liao J, Zheng Y, Huang G, Adami HO, Zeng Y, Zhang Z, Ye W. Debelius JW, et al. mSystems. 2020 Jul 7;5(4):e00065-20. doi: 10.1128/mSystems.00065-20. mSystems. 2020. PMID: 32636333 Free PMC article.
Influence of Pre-treatment Saliva Microbial Diversity and Composition on Nasopharyngeal Carcinoma Prognosis.
Du Y, Feng R, Chang ET, Debelius JW, Yin L, Xu M, Huang T, Zhou X, Xiao X, Li Y, Liao J, Zheng Y, Huang G, Adami HO, Zhang Z, Cai Y, Ye W. Du Y, et al. Front Cell Infect Microbiol. 2022 Mar 22;12:831409. doi: 10.3389/fcimb.2022.831409. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35392614 Free PMC article.

See all "Cited by" articles

References

1. Yuan JM, Wang XL, Xiang YB, Gao YT, Ross RK, Yu MC. Non-dietary risk factors for nasopharyngeal carcinoma in Shanghai, China. Int J Cancer. 2000;85:364–369. - PubMed
1. Yuan JM, Wang XL, Xiang YB, Gao YT, Ross RK, Yu MC. Preserved foods in relation to risk of nasopharyngeal carcinoma in Shanghai, China. Int J Cancer. 2000;85:358–363. - PubMed
1. Chang ET, Adami HO. The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 2006;15:1765–1777. - PubMed
1. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr/, accessed on June, 2016.
1. Forman D, Bray F, Brewster DH, Gombe Mbalawa C, Kohler B, Piñeros M, Steliarova-Foucher E, Swaminathan R, Ferlay J. Cancer Incidence in Five Continents. Lyon: IARC; 2013. Vol X (electronic version) - PubMed

Grants and funding

R01 CA115873/CA/NCI NIH HHS/United States

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Development of a population-based cancer case-control study in southern china

Affiliations

Development of a population-based cancer case-control study in southern china

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources