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. 2017 Oct 4;8(50):88152-88162.
doi: 10.18632/oncotarget.21538. eCollection 2017 Oct 20.

COX-2 expression in ovarian cancer: an updated meta-analysis

Haiming Sun  1   2 , Xuelong Zhang  1 , Donglin Sun  1 , Xueyuan Jia  1 , Lidan Xu  1 , Yuandong Qiao  1 , Yan Jin  1
Affiliations

COX-2 expression in ovarian cancer: an updated meta-analysis

Haiming Sun et al. Oncotarget. .

Abstract

The prognostic role of COX-2 expression in ovarian cancer patients has been studied for years, while results remain controversial. Thus we performed a meta-analysis to evaluate the prognostic impact of COX-2 expression on survival of ovarian cancer patients. The databases PubMed, Embase and CNKI were searched. Summary hazard ratio (HR) and 95% confidence intervals (CIs) were calculated to analyze the correlations between COX-2 expression and overall survival (OS), and disease-free survival (DFS). A total of 1,867 patients from 18 studies were enrolled in the final analysis. The results showed that patients with higher COX-2 expression had a poor OS (HR: 1.48; 95% CI: 1.19-1.85) and DFS (HR: 1.81, 95% CI: 1.28-2.55). Subgroup analysis showed that there had significant associations between COX-2 expression and survival rate in most of the subgroups. Furthermore, there were significant associations between COX-2 expression and several clinical parameters such as FIGO stage, histological type and age. These results showed the patients with higher COX-2 expression had a significantly poorer survival rate, COX-2 expression had the potential to be a prognostic marker of ovarian cancer.

Keywords: COX-2; meta-analysis; ovarian cancer; prognosis.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no competing financial interests.

Figures

Figure 1
Figure 1. Flow chart of the literature search
Figure 2
Figure 2. Forest plots of hazard ratios (HRs) for the association between COX-2 expression and overall survival (OS) in ovarian cancer patients
The 95% confidence intervals (CI) for individual studies are represented by a horizontal line and by a diamond for pooled effect. CI denotes confidence interval.
Figure 3
Figure 3. Forest plots of hazard ratios (HRs) for the association between COX-2 expression and disease-free survival (DFS) in ovarian cancer patients
The 95% confidence intervals (CI) for individual studies are represented by a horizontal line and by a diamond for pooled effect. CI denotes confidence interval.
Figure 4
Figure 4
Sensitive analysis of the pooled hazard ratio for OS (A) and DFS (B). Meta-analysis random effects estimates were used. Results were computed by omitting each study (on the left) in turn. The two ends of every broken line represented the 95% confidence interval.
Figure 5
Figure 5
Funnel plot for the assessment of publication bias of the included literature for OS (A) and DFS (B).
See this image and copyright information in PMC

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