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Editorial
. 2017 Sep 12;9(9):e1679.
doi: 10.7759/cureus.1679.

On the Horizon: The Synthetic Opioid U-49900

Saeed K Alzghari  1 , Zubair M Amin  2 , Sophie Chau  3 , Steven W Fleming  4 , Kevin Cho  4 , Victor Fung  5
Affiliations
Editorial

On the Horizon: The Synthetic Opioid U-49900

Saeed K Alzghari et al. Cureus. .

Abstract

Synthetic opioid use continues to be a problem in the United States. New designer opioids continue to be released as "research chemicals" by vendors, leading to widespread use and potentially devastating consequences. U-49900 is a new synthetic opioid with limited clinical data available. Herein, we provide an overview of U-49900, the anecdotal accounts of U-49900 use that clinicians need to be made aware of, and a call for the federal government to take immediate action in curtailing the use of U-49900.

Keywords: drugs of abuse; opioid abuse; opioids; research chemical; synthetic opioid; u-49900.

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Conflict of interest statement

The authors have declared financial relationships, which are detailed in the next section.

Figures

Figure 1
Figure 1. Chemical structure of U-49900
See this image and copyright information in PMC

References

    1. Metabolism of novel opioid agonists U-47700 and U-49900 using human liver microsomes with confirmation in authentic urine specimens from drug users. Krotulski AJ, Mohr ALA, Papsun DM, Logan BK. Drug Test Anal. 2017 - PubMed
    1. Schedules of controlled substances: temporary placement of U-47700 into schedule I. Final order. Drug Enforcement Administration, Department of Justice. https://www.gpo.gov/fdsys/pkg/FR-2016-11-14/pdf/2016-27357.pdf. Fed Regist. 2016;81:79389–79393. - PubMed
    1. Updating the list of known opioids through identification and characterization of the new opioid derivative 3,4-dichloro-N-(2-(diethylamino)cyclohexyl)-N-methylbenzamide (U-49900) Fabregat-Safont D, Carbón X, Ventura M, et al. Sci Rep. 2017;7:6338. - PMC - PubMed
    1. Research chemicals. [Aug;2017 ];https://www.reddit.com/r/researchchemicals/ 2017
    1. North Carolina General Assembly House Bill 464/Session Law 2017-115. [Aug;2017 ];http://www.ncleg.net/gascripts/BillLookUp/BillLookUp.pl?BillID=H464&Sess... 2017

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