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Review
. 2017 Oct;5(20):399.
doi: 10.21037/atm.2017.06.50.

Integrating surgery and genetic testing for the modern surgeon

Raul Caso  1 , Matthew Beamer  1 , Alexander D Lofthus  1 , Michael Sosin  1
Affiliations
Review

Integrating surgery and genetic testing for the modern surgeon

Raul Caso et al. Ann Transl Med. 2017 Oct.

Abstract

The field of cancer genetics is rapidly evolving and several genetic mutations have been identified in hereditary cancer syndromes. These mutations can be diagnosed via routine genetic testing allowing prompt intervention. This is especially true for certain variants of colorectal, breast, and thyroid cancers where genetic testing may guide surgical therapy. Ultimately, surgical intervention may drastically diminish disease manifestation or progression in individuals deemed as high-risk based on their genetic makeup. Understanding the concepts of gene-based testing and integrating into current surgical practice is crucial. This review addresses common genetic syndromes, tests, and interventions salient to the current surgeon.

Keywords: Breast cancer; familial adenomatous polyposis (FAP); genetic testing; hereditary nonpolyposis colorectal cancer (HNPCC); multiple endocrine neoplasms.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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